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616371 Sigma-AldrichAprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem

Aprotinin, Bovine, Recombinant, Nicotiana sp, Animal-Free - CAS 9087-70-1, is a heat and acid-stable competitive, reversible inhibitor of serine proteases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor, Kallikrein-Trypsin Inactivator, Antikrein, Basic Pancreatic Trypsin Inhibitor

Primary Target: chymotrypsin

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
9087-70-1	C₂₈₄H₄₃₂N₈₄O₇₉S₇

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
616371-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
616371-25MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	25 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	Recombinant, bovine aprotinin supplied without animal-derived components. Aprotinin is a competitive, reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (K_d = 5 x 10^-14 M), plasmin (K_d = 2.3 x 10^-10 M), and kallikrein (K_d = 1 x 10^-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful for protein purification and for extending the life of cells in culture by preventing proteolytic damage.
Catalogue Number	616371
Brand Family	Calbiochem®
Synonyms	Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor, Kallikrein-Trypsin Inactivator, Antikrein, Basic Pancreatic Trypsin Inhibitor

References
References	Deutscher, M.P., 1990. Methods Enzymol. 182, 83.

Product Information
CAS number	9087-70-1
Unit of Definition	One TIU (Trypsin Inhibitory Unit) will decrease the activity of two trypsin units by 50% where one trypsin unit will hydrolyze 1.0 µmole of Nα-benzoyl-L-Arginine-p-Nitroanilide (L-BAPNA) per minute at pH 7.8 at 25°C.
ATP Competitive	N
EC number	2329949
Form	White to off-white powder
Formulation	Contains no animal-derived components.
Hill Formula	C₂₈₄H₄₃₂N₈₄O₇₉S₇
Chemical formula	C₂₈₄H₄₃₂N₈₄O₇₉S₇
Reversible	Y
Quality Level	MQ200

Applications

Biological Information
Primary Target	chymotrypsin
Primary Target IC<sub>50</sub>	Kd = 5 x 10-14 M, 2.3 x 10-10 M, 1 x 10-7 M against trypsin, plasmin, and kallikrein, respectively
Purity	≥98% by SDS-PAGE
Specific Activity	≥5.0 EPU/mg protein
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	YN5080000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Ok to freeze

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
616371-1MGCN	04055977262919
616371-25MGCN	04055977262926
616371-5MGCN	04055977262933

Documentation

Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem 分析证书

标题	批号
616371	输入批号

参考

参考信息概述
Deutscher, M.P., 1990. Methods Enzymol. 182, 83.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	08-August-2024 JSW
Synonyms	Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor, Kallikrein-Trypsin Inactivator, Antikrein, Basic Pancreatic Trypsin Inhibitor
Description	Recombinant, bovine aprotinin supplied without animal-derived components. Aprotinin is a competitive, reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (K_d = 5 x 10^-14 M), plasmin (K_d = 2.3 x 10^-10 M), and kallikrein (K_d = 1 x 10^-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful for protein purification and for extending the life of cells in culture by preventing proteolytic damage.
Form	White to off-white powder
Formulation	Contains no animal-derived components.
Concentration Label	Please refer to vial label for lot-specific concentration
CAS number	9087-70-1
RTECS	YN5080000
EC number	2329949
Chemical formula	C₂₈₄H₄₃₂N₈₄O₇₉S₇
Purity	≥98% by SDS-PAGE
Specific activity	≥5.0 EPU/mg protein
Unit definition	One TIU (Trypsin Inhibitory Unit) will decrease the activity of two trypsin units by 50% where one trypsin unit will hydrolyze 1.0 µmole of Nα-benzoyl-L-Arginine-p-Nitroanilide (L-BAPNA) per minute at pH 7.8 at 25°C.
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Toxicity	Standard Handling
Merck USA index	14, 757
References	Deutscher, M.P., 1990. Methods Enzymol. 182, 83.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors

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