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616370 Sigma-AldrichAprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem

Aprotinin, Bovine Lung, Crystalline, CAS 9087-70-1, is a competitive, reversible, heat- and acid-stable inhibitor of proteolytic and esterolytic activities.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor

Primary Target: chymotrypsin

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概述

Replacement Information

重要规格表

CAS #
9087-70-1

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
616370-100MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	100 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
616370-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A competitive and reversible inhibitor of esterases and proteases. Forms a tight complex with and blocks the active site of the enzymes. Inhibits a number of different proteases, including chymotrypsin, coagulation factors involved in the prephase of blood clotting, kallikrein (K_d= 1 x 10^-7 M), plasmin (K_d= 2.3 x 10^-10M), tissue and leukocytic proteinases, and trypsin (K_d= 5 x 10^-14 M). Does not inhibit Factor Xa and thrombin. It is relatively acid- and heat-stable. Useful as a serine protease inhibitor during purification of proteins and in studies of zymogen activation systems. Reported to suppress virus HA cleavage and limit reproduction of human and avian influenza viruses with a single arginine in the HA cleavage site.
	Effectively inhibits target proteases at equimolar concentration.
	Note: 1 KIU = 0.025 antiplasmin units (APU) = 0.0016 trypsin inhibitor units (using porcine trypsin) = 0.0009756 trypsin inhibitor units (using bovine trypsin).
Catalogue Number	616370
Brand Family	Calbiochem®
Synonyms	Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor

References
References	Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27. Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225. Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185. Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979. Kruithof, W.L., et al. 1986. Biochem. J. 226, 631. McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378. Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479. Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035. Kassell, B., et al. 1970. Methods Enzymol. 19, 845.

References

Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
Kassell, B., et al. 1970. Methods Enzymol. 19, 845.

Product Information
CAS number	9087-70-1
Activity	≥5500 KIU/mg dry weight
Unit of Definition	One Kallikrein Inhibitory Unit (K.I.U.) is defined as the quantity of protease inhibitor that will inhibit two kallikrein units by 50% under optimal conditions. Note: 1 KIU = 0.025 antiplasmin units (APU) or 0.0031 trypsin inhibitor units.
ATP Competitive	N
Form	White to off-white crystalline solid
Hygroscopic	Hygroscopic
PI	10.5
Reversible	Y
Quality Level	MQ200

Applications

Biological Information
Primary Target	chymotrypsin
Primary Target IC<sub>50</sub>	Kd = 1 x 10-7 M, 2.3 x 10-10 M, 5 x 10-14 M, against kallikrein, plasmin, and trypsin, respectively
Purity	≥95% by gel filtration

Physicochemical Information
Cell permeable	N
Contaminants	endotoxin: ≤10 EU/mg

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	YN5080000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
616370-100MGCN	04055977262889
616370-10MGCN	07790788056292
616370-20MGCN	04055977262896

Documentation

Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem 分析证书

标题	批号
616370	输入批号

参考

参考信息概述
Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27. Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225. Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185. Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979. Kruithof, W.L., et al. 1986. Biochem. J. 226, 631. McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378. Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479. Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035. Kassell, B., et al. 1970. Methods Enzymol. 19, 845.

参考信息概述

小册子

标题
Bulk Product Guide

引用

标题

Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-February-2012 RFH
Synonyms	Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor
Description	A competitive and reversible inhibitor of esterase and protease activity. Forms a tight complex with and blocks the active site of target enzymes. Inhibits a number of different proteases, including chymotrypsin, coagulation factors involved in the pre-phase of blood clotting, kallikrein (K_d = 1 X 10^-7 M), plasmin (K_d = 2.3 X 10^-10 M), tissue and leukocyte proteinases, and trypsin (K_d = 5 X 10^-14 M). Does not inhibit Factor Xa or thrombin. Reported to be relatively acid and heat stable. Effectively inhibits target proteases at equimolar concentration. Useful as a serine proteinase inhibitor during purification of proteins and in studies of zymogen activation systems. Reported to suppress virus HA cleavage and limit reproduction of human and avian influenza viruses with a single arginine in the HA cleavage site.
Form	White to off-white crystalline solid
CAS number	9087-70-1
RTECS	YN5080000
Purity	≥95% by gel filtration
Contaminants	endotoxin: ≤10 EU/mg
Activity	≥5500 KIU/mg dry weight
Unit definition	One Kallikrein Inhibitory Unit (K.I.U.) is defined as the quantity of protease inhibitor that will inhibit two kallikrein units by 50% under optimal conditions. Note: 1 KIU = 0.025 antiplasmin units (APU) or 0.0031 trypsin inhibitor units.
Solubility	H₂O (10 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
Toxicity	Standard Handling
Merck USA index	14, 757
References	Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27. Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225. Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185. Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979. Kruithof, W.L., et al. 1986. Biochem. J. 226, 631. McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378. Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479. Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035. Kassell, B., et al. 1970. Methods Enzymol. 19, 845.
Citation	Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors

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