178494 Sigma-AldrichApoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem
The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
More>> The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: NS3694
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 426834-38-0 | C₁₅H₁₀ClF₃N₂O₃ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
|---|---|---|---|---|---|---|
| 178494-10MGCN |
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塑胶安瓿;塑胶针药瓶 | 10 mg |
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| Description | |
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| Overview | A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases. |
| Catalogue Number | 178494 |
| Brand Family | Calbiochem® |
| Synonyms | NS3694 |
| References | |
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| References | Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829. |
| Product Information | |
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| CAS number | 426834-38-0 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₁₅H₁₀ClF₃N₂O₃ |
| Chemical formula | C₁₅H₁₀ClF₃N₂O₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Apoptosome complex formation |
| Primary Target IC<sub>50</sub> | 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 178494-10MGCN | 04055977204803 |
Documentation
Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem MSDS
| 职位 |
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Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem 分析证书
| 标题 | 批号 |
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| 178494 |
参考
| 参考信息概述 |
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| Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829. |