Millipore Sigma Vibrant Logo

178488 Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem

The Apoptosis Inhibitor, also referenced under CAS 54135-60-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: M50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)

Primary Target: apoptosis induction
View Products on Sigmaaldrich.com
178488
查看价格及供货情况

概述

Replacement Information

重要规格表

CAS #Empirical Formula
54135-60-3C₁₃H₁₆O₄

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
178488-10MGCN
正在查询供货情况......
—
目前缺货 目前缺货
有货 
停产
少量现货
供货情况有待确认
    其余：另行通知
      其余：另行通知
      另行通知
      联系客户服务
      Contact Customer Service

      		 塑胶安瓿;塑胶针药瓶 10 mg
      正在检索价格......
      无法检索价格。
      最小订购数量为倍数
      Maximum Quantity is
      以订单确认为准 更多信息
      您节约了 ()。
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable inhibitor of apoptosis induction (IC50 = 67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells). Effects attributable to the inhibition of caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.
      Catalogue Number178488
      Brand Family Calbiochem®
      SynonymsM50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
      References
      ReferencesTsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.
      Product Information
      CAS number54135-60-3
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₃H₁₆O₄
      Chemical formulaC₁₃H₁₆O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetapoptosis induction
      Primary Target IC<sub>50</sub>67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      178488-10MGCN 04055977204780

      Documentation

      Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem 分析证书

      标题批号
      178488

      参考

      参考信息概述
      Tsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.

      小册子

      标题
      Caspases and other Apoptosis Related Tools Brochure
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-July-2009 RFH
      SynonymsM50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
      DescriptionA cell-permeable, bis(cyclohexane-1,3-diketone) that is shown to inhibit apoptosis induction in FasL-stimulated WC8 cells (IC50 = 67 µg/ml) and etoposide-stimulated U937 cells (IC50 = 130 µg/ml). The anti-apoptotic effects have been shown to be attributable to inhibition of caspase-3 activation (IC50 = 334 nM), however it does not exhibit any direct inhibition of caspase-3 enzymatic activity. Shown to inhibit the elevation of the liver enzymes, alanine aminotransferase and aspartate aminotransferase, in a murine model of anti-Fas-induced hepatitis. Topical application has been shown to reduce chemotherapy-induced alopecia (hair loss) in newborn rats.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number54135-60-3
      Chemical formulaC₁₃H₁₆O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (20 mg/ml)
      Storage Protect from moisture
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.