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A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).
Catalogue Number
178385
Brand Family
Calbiochem®
Synonyms
4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
References
References
Abid, M.R., et al. 2000. FEBS Lett.486, 252. Muijsers, R.B., et al. 2000. Br. J. Pharmacol.130, 932. Lapperre, T.S., et al. 1999. FEBS Lett.443, 235. Supinski, G., et al. 1999, J. Appl. Physiol.87, 776. van der Goes, A., et al. 1998. J. Neuroimmunol.92, 67. Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.
Abid, M.R., et al. 2000. FEBS Lett.486, 252. Muijsers, R.B., et al. 2000. Br. J. Pharmacol.130, 932. Lapperre, T.S., et al. 1999. FEBS Lett.443, 235. Supinski, G., et al. 1999, J. Appl. Physiol.87, 776. van der Goes, A., et al. 1998. J. Neuroimmunol.92, 67. Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
27-February-2018 JSW
Synonyms
4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
Description
A cell-permeable, anti-inflammatory phenol that acts as a potent and selective inhibitor of NADPH oxidase. Also blocks peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through the activation of AP-1. Shown to prevent phagocytosis of myelin by macrophages (10 mM).
Form
White to off-white powder
Intert gas (Yes/No)
Packaged under inert gas
CAS number
498-02-2
RTECS
AM8800000
Chemical formula
C₉H₁₀O₃
Structure formula
Purity
≥98% by GC
Solubility
DMSO (10 mg/ml) or Ethanol (20 mg/ml)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Irritant
Merck USA index
14, 741
References
Abid, M.R., et al. 2000. FEBS Lett.486, 252. Muijsers, R.B., et al. 2000. Br. J. Pharmacol.130, 932. Lapperre, T.S., et al. 1999. FEBS Lett.443, 235. Supinski, G., et al. 1999, J. Appl. Physiol.87, 776. van der Goes, A., et al. 1998. J. Neuroimmunol.92, 67. Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.