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178385 Sigma-AldrichApocynin - CAS 498-02-2 - Calbiochem

A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.

Apocynin - CAS 498-02-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V

Primary Target: NADPH oxidase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
498-02-2	C₉H₁₀O₃

价格及供货情况

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Description
Overview	A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).
Catalogue Number	178385
Brand Family	Calbiochem®
Synonyms	4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V

References
References	Abid, M.R., et al. 2000. FEBS Lett. 486, 252. Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932. Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235. Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776. van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67. Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.

Product Information
CAS number	498-02-2
ATP Competitive	N
Form	White to off-white powder
Hill Formula	C₉H₁₀O₃
Chemical formula	C₉H₁₀O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	NADPH oxidase
Purity	≥98% by GC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	AM8800000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
178385-1GMCN	04055977222463

Documentation

Apocynin - CAS 498-02-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Apocynin - CAS 498-02-2 - Calbiochem 分析证书

标题	批号
178385	输入批号

参考

参考信息概述
Abid, M.R., et al. 2000. FEBS Lett. 486, 252. Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932. Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235. Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776. van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67. Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.

小册子

标题
Pathways and Biomarkers of Oxidative Stress

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-February-2018 JSW
Synonyms	4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
Description	A cell-permeable, anti-inflammatory phenol that acts as a potent and selective inhibitor of NADPH oxidase. Also blocks peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through the activation of AP-1. Shown to prevent phagocytosis of myelin by macrophages (10 mM).
Form	White to off-white powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	498-02-2
RTECS	AM8800000
Chemical formula	C₉H₁₀O₃
Structure formula
Purity	≥98% by GC
Solubility	DMSO (10 mg/ml) or Ethanol (20 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Irritant
Merck USA index	14, 741
References	Abid, M.R., et al. 2000. FEBS Lett. 486, 252. Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932. Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235. Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776. van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67. Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress

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