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178278 Sigma-AldrichApigenin - CAS 520-36-5 - Calbiochem

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM).

Apigenin - CAS 520-36-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 4ʹ,5,7-Trihydroxyflavone

Primary Target: MAP kinase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
520-36-5	C₁₅H₁₀O₅

价格及供货情况

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Description
Overview	Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G₂/M arrest and induces morphological differentiation.
Catalogue Number	178278
Brand Family	Calbiochem®
Synonyms	4ʹ,5,7-Trihydroxyflavone

References
References	Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767. Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325. Kuo, M.L., et al. 1994. Cancer Lett. 87, 91. Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.

Product Information
CAS number	520-36-5
ATP Competitive	N
Form	Yellow crystalline solid
Hill Formula	C₁₅H₁₀O₅
Chemical formula	C₁₅H₁₀O₅
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	MAP kinase
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	LK9276000

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 36-26 Wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
178278-5MGCN	04055977222425

Documentation

Apigenin - CAS 520-36-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Apigenin - CAS 520-36-5 - Calbiochem 分析证书

标题	批号
178278	输入批号

参考

参考信息概述
Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767. Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325. Kuo, M.L., et al. 1994. Cancer Lett. 87, 91. Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-March-2009 RFH
Synonyms	4ʹ,5,7-Trihydroxyflavone
Description	A plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44^mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G₂/M arrest and to induce morphological differentiation.
Form	Yellow crystalline solid
CAS number	520-36-5
RTECS	LK9276000
Chemical formula	C₁₅H₁₀O₅
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (10 mg/ml) or hot Ethanol (1 mg/ml)
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.
Toxicity	Irritant
Merck USA index	14, 730
References	Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767. Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325. Kuo, M.L., et al. 1994. Cancer Lett. 87, 91. Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors

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