数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

178276 Sigma-AldrichApicidin, Fusarium sp. - Calbiochem

A potent, cell-permeable inhibitor of histone deacetylase (IC₅₀= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties.

Apicidin, Fusarium sp. - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
技术信息
Data Sheet

同义词: cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI

Primary Target: Histone deacetylase

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₃₄H₄₉N₅O₆

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
178276-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	铝滚桶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
178276-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	铝滚桶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A potent, cell-permeable inhibitor of histone deacetylase (IC₅₀= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC₅₀= 50-100 nM) and induces the transcriptional activation of p21 (WAF1). Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2.
Catalogue Number	178276
Brand Family	Calbiochem®
Synonyms	cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI

References
References	Colletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107. Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866. Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761. Kim, M.S., et al. 2000. Cancer Lett. 157, 23. Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.

Product Information
ATP Competitive	N
Form	White solid
Hill Formula	C₃₄H₄₉N₅O₆
Chemical formula	C₃₄H₄₉N₅O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Histone deacetylase
Primary Target IC<sub>50</sub>	700 pM for parasitic histone deactetylase
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 26/27/28 Very toxic by inhalation, in contact with skin and if swallowed.
S Phrase	S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Highly Toxic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
178276-1MGCN	04055977222401
178276-5MGCN	04055977222418

Documentation

Apicidin, Fusarium sp. - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Apicidin, Fusarium sp. - Calbiochem 分析证书

标题	批号
178276	输入批号

参考

参考信息概述
Colletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107. Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866. Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761. Kim, M.S., et al. 2000. Cancer Lett. 157, 23. Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.

技术信息

标题
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-February-2019 JSW
Synonyms	cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
Description	A potent, cell-permeable inhibitor of histone deacetylase (IC₅₀ = 700 pM for parasitic histone deactetylase) that also exhibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC₅₀ = 50-100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2 in a reversible manner.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₃₄H₄₉N₅O₆
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml) or Ethanol
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Highly Toxic
References	Colletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107. Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866. Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761. Kim, M.S., et al. 2000. Cancer Lett. 157, 23. Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors

此产品已添加到您的购物车。