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07-833 Sigma-AldrichAnti-phospho-Gab1 (Tyr627) Antibody

This Anti-phospho-Gab1 (Tyr627) Antibody is validated for use in WB for the detection of phospho-Gab1 (Tyr627).

Anti-phospho-Gab1 (Tyr627) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考

Research Category: Signaling Research Sub-Category: MAP Kinases Gene Symbol: GAB1 UniProt Number: Q13480

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	07-833
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-phospho-Gab1 (Tyr627) Antibody
Alternate Names	GAB1 GRB2-associated binding protein 1

References

Product Information
Format	Affinity Purified
Presentation	100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
Quality Level	MQ100

Applications
Application	This Anti-phospho-Gab1 (Tyr627) Antibody is validated for use in WB for the detection of phospho-Gab1 (Tyr627).
Key Applications	Western Blotting
Application Notes	Immunoblot Analysis: 1:1000 dilutions of this lot detected phospho-Gab1 (Tyr627) in RIPA lysate of PDGF treated NIH3T3 cells.

Biological Information
Immunogen	Peptide corresponding to amino acid region encompassing the human and mouse phospho-Gab1 (Tyr627)
Host	Rabbit
Specificity	Gab1 phosphorylated on Tyrosine residue 627.
Isotype	IgG
Species Reactivity	Mouse
Species Reactivity Note	Predicted to cross-react with human based on 100% sequence homology, but have not been tested.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_002039.2 NM_207123.1
Entrez Gene Summary	The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. The encoded protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
Gene Symbol	GAB1
Modifications	Phosphorylation
Purification Method	Affinity Purfied
UniProt Number	Q13480
UniProt Summary	FUNCTION: SwissProt: Q13480 # Probably involved in EGF and insulin receptor signaling. SIZE: 694 amino acids; 76616 Da SUBUNIT: Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. PTM: Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. SIMILARITY: SwissProt: Q13480 ## Belongs to the GAB family. & Contains 1 PH domain.
Molecular Weight	115 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by immunoblot.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

Storage and Shipping Information

Storage Conditions

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
07-833	04053252469459

Documentation

Anti-phospho-Gab1 (Tyr627) Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-phospho-Gab1 (Tyr627) Antibody 分析证书

标题	批号
Anti-phospho-Gab1 (Tyr627) (Affinity purified Rabbit polyclonal IgG)	3115880
Anti-phospho-Gab1 (Tyr627) (Affinity purified Rabbit polyclonal IgG) - DAM1465948	DAM1465948
Anti-phospho-Gab1 (Tyr627) - 1988572	1988572
Anti-phospho-Gab1 (Tyr627) - DAM1413923	DAM1413923
anti-phospho-Gab1 (Tyr627) - 0604027241	0604027241
anti-phospho-Gab1 (Tyr627) - 0604027242	0604027242
anti-phospho-Gab1 (Tyr627) - 0610042766	0610042766
anti-phospho-Gab1 (Tyr627) - 0612047427	0612047427
anti-phospho-Gab1 (Tyr627) - JBC1378200	JBC1378200

参考

参考概述	公共医疗ID
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progressio Bourguignon, Lilly Y W, et al J Biol Chem, 278:29420-34 (2003) 2003	12748184
Roles of cell-cell adhesion-dependent tyrosine phosphorylation of Gab-1 Shinohara, M, et al J Biol Chem, 276:18941-6 (2001) 2001	11262408
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway Boccaccio, C, et al Nature, 391:285-8 (1998) 1998	9440692
A Grb2-associated docking protein in EGF- and insulin-receptor signalling Holgado-Madruga, M, et al Nature, 379:560-4 (1996) 1996	8596638

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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