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MABN833 Sigma-AldrichAnti-phospho Drebrin (Ser142), clone 3C14 Antibody

Anti-phospho Drebrin (Ser142), clone 3C14 | MABN833 is an antibody against phospho Drebrin for use in Western Blotting, Immunocytochemistry, Peptide Inhibition Assay.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: Dbn1 UniProt Number: Q07266

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R, H, M	WB, ICC, PIA	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN833
Description	Anti-phospho Drebrin (Ser142), clone 3C14 Antibody
Alternate Names	Drebrin Developmentally-regulated brain protein
Background Information	Developmentally-regulated brain protein, also known as Drebrin, and encoded by the gene name DBN1, is a developmentally-regulated neuron-specific protein, expressed during outgrowth and maturation of dendrites, and localized within dendrites of the adult brain. Drebrin is required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. Recent studies have shown that Drebrins may play a role in cell migration, extension of neuronal processes and plasticity of dendrites. Drebrins are classified into two forms of the embryonic type (E1 and E2) and one form of the adult type (A). The time course of their appearance are different from each other. Their structures are closely related. Adult rat brain expresses only drebrin A while drebrin E1 or E2 is observed in immature animals. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals have been observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of Drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of Drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast. Drebrin is expressed mainly in brain neurons.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-phospho Drebrin (Ser142), clone 3C14 \| MABN833 is an antibody against phospho Drebrin for use in Western Blotting, Immunocytochemistry, Peptide Inhibition Assay.
Key Applications	Western Blotting Immunocytochemistry Peptide Inhibition Assay
Application Notes	Western Blotting Analysis: 0.5 µg/mL from a representative lot detected phospho Drebrin (Ser142) in 10 µg of rat neonatal brain tissue lysate. Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected phospho Drebrin (Ser142) in HeLa and NIH/3T3 cells. Peptide Inhibition Analysis: 0.5 µg/mL from a representative lot detected phospho Drebrin (Ser142) in 10 µg of rat neonatal brain tissue lysate. Immunocytochemistry Analysis: A representative lot detected phospho Drebrin (Ser142) in rat embryonic cortical culture (Prof. Phillip R. Gordon-Weeks, King's College London).

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to rat phospho Drebrin (Ser142).
Clone	3C14
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG3κ
Species Reactivity	Rat Human Mouse
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_112286
Gene Symbol	Dbn1
Purification Method	Protein G Purified
UniProt Number	Q07266
Molecular Weight	~100 kDa observed. The calculated molecular weight is 71 kDa, however phospho Drebrin (Ser142) has been shown as a ~100 kDa band in western blots (Worth, D.C., et al. (2013). JCB. 202(5):793-806).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in SH-SY5Y cell lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected phospho Drebrin (Ser142) in 10 µg of SH-SY5Y cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN833	04055977123876

Documentation

Anti-phospho Drebrin (Ser142), clone 3C14 Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-phospho Drebrin (Ser142), clone 3C14 Antibody 分析证书

标题	批号
Anti-phospho Drebrin (Ser142), clone 3C14 - 2986023	2986023
Anti-phospho Drebrin (Ser142), clone 3C14 - 3506405	3506405
Anti-phospho Drebrin (Ser142), clone 3C14 - 3906460	3906460
Anti-phospho Drebrin (Ser142), clone 3C14 - 3982076	3982076
Anti-phospho Drebrin (Ser142), clone 3C14 - 4092638	4092638
Anti-phospho Drebrin (Ser142), clone 3C14 -Q2495631	Q2495631
Anti-phospho Drebrin (Ser142), clone 3C14 Monoclonal Antibody	3150355
Anti-phospho Drebrin (Ser142), clone 3C14 Monoclonal Antibody	3316658

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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