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ABN161-I Sigma-AldrichAnti-pan Neurexin-1 Antibody

Anti-pan Neurexin-1 Antibody detects level of pan Neurexin-1 and has been published and validated for use in Western Blotting, Immunohistochemistry (Paraffin).

Anti-pan Neurexin-1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
小册子

Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: Nrxn1, Kiaa0578 UniProt Number: Q9CS84

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M, R, H	WB, IH(P)	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	ABN161-I
Replaces	ABN161
Description	Anti-pan Neurexin-1 Antibody
Alternate Names	Neurexin-1 Neurexin-1-alpha Neurexin I-alpha
Background Information	Neurexin-1 (UniProt Q9CS84; also known as Neurexin I-alpha, Neurexin-1-alpha) is encoded by the Nrxn1 (also known as Kiaa0578) gene (Gene ID 18189) in murine species. Neurexin (NRXN) is a presynaptic single pass transmembrane protein that assists in joining neurons together at the synapse. Neurexins mediate signaling across the synapse and neural networks by specifying synpatic function. Mutations in the genes encoding for neurexins are implicated in autism, schizphrenia, and nicotine dependence. There are two classifications of neurexins, α-NRXNs and β-NRXNs. The α-NRXNs are larger and have different amino-terminal extracellular sequences than β-NRXNs. β-NRXNs act as receptors for neuroligin and have been found to play a role in angiogenesis.

References

Product Information
Format	Affinity Purified
Presentation	Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-pan Neurexin-1 Antibody detects level of pan Neurexin-1 and has been published and validated for use in Western Blotting, Immunohistochemistry (Paraffin).
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Neurexin-1 in mouse, rat, and human cerebral cortex tissue sections.

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to a cytoplasmic domain sequence near the C-teminus of mouse neurexin-1.
Epitope	Near C-terminus.
Concentration	Please refer to lot specific datasheet.
Host	Rabbit
Specificity	Expected to react with all neurexin-1-alpha and neurexin-1-beta spliced isoforms of murine, human, and rat species, as this polyclonal antibody targets the C-terminal end cytoplasmic sequence that is not affected by alternative splicings (Missler, M., and Südhof, T.C. (1998). Trends Genet. 14(1):20-26). Cross-reactivities toward alpha and beta isoforms of neurexin-2 and neurexin-3 are also likely, although the C-termminal sequence is not 100% conserved among neurexin-1, neurexin-2 and neurexin-3.
Species Reactivity	Mouse Rat Human
Species Reactivity Note	Mouse, Rat, Human. Predicted to react with Bovine based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_796258
Gene Symbol	Nrxn1 Kiaa0578
Purification Method	Affinity Purfied
UniProt Number	Q9CS84
Molecular Weight	~170/55/40 kDa observed. Varible depending on the isoform(s) present in the test sample(s).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in mouse brain tissue lysate. Western Blotting Analysis: 0.2 µg/mL of this antibody detected Neurexin-1 in 10 µg of mouse brain tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABN161-I	04055977314199

Documentation

Anti-pan Neurexin-1 Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-pan Neurexin-1 Antibody 分析证书

标题	批号
Anti-pan Neurexin-1 - 3212323	3212323
Anti-pan Neurexin-1 - 3218767	3218767
Anti-pan Neurexin-1 - 3251458	3251458
Anti-pan Neurexin-1 - 3305870	3305870
Anti-pan Neurexin-1 - 3457054	3457054
Anti-pan Neurexin-1 - 4097737	4097737
Anti-pan Neurexin-1 - 4197958	4197958
Anti-pan Neurexin-1 -2819305	2819305
Anti-pan Neurexin-1 -Q2640658	Q2640658
Anti-pan Neurexin-1 Polyclonal Antibody	3129227

小册子

标题
Neuroscience Solutions for productive research

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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