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MABC608 Sigma-AldrichAnti-dUTPase Antibody, clone 6A6.2

Anti-dUTPase Antibody, clone 6A6.2 is an antibody against dUTPase for use in Western Blotting, Immunocytochemistry.

Anti-dUTPase Antibody, clone 6A6.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
技术信息

Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: DUT UniProt Number: P33316

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, ICC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABC608
Description	Anti-dUTPase Antibody, clone 6A6.2
Alternate Names	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial dUTPase dUTP pyrophosphatase
Background Information	Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23; also known as dUTPase, dUTP nucleotidohydrolase, or dUTP pyrophosphatase) is encoded by the DUT gene (Entrez Gene ID 1854) in human. dUTPase catalyzes the hydrolysis of dUTP to generate dUMP. This reaction serves to provide dUMP of thymine nucleotides synthesis needed for DNA replication. dUTP hydrolysis by dUTPase also prevents increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. The DUT gene encodes both mitochondrial and nuclear dATPase (DUT-M and DUT-N, respectively) via alternative splicing. DUT-N (164 aa, 17.7 kDa) corresponds to DUT-M (252 aa, 26.6 kDa) with the first 93 amino acid sequence replaced by MPCSE. Cat. No. MABC608, Anti-dUTPase, clone 6A6.2, is a purified mouse monoclonal antibody. A GST fusion protein containing the full-lenght human DUT-N (UniProt P33316) sequence was used as the immunogen. The binding epitope of clone 6A6.2 is not yet mapped.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ300

Applications
Application	Anti-dUTPase Antibody, clone 6A6.2 is an antibody against dUTPase for use in Western Blotting, Immunocytochemistry.
Key Applications	Western Blotting Immunocytochemistry
Application Notes	Immunocytochemistry Analysis: 4.0 µg/mL from a representative lot detected dUTPase in HeLa and A431 cells.

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to human dUTPase.
Clone	6A6.2
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG2bκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_001020419
Gene Symbol	DUT
Purification Method	Protein G Purified
UniProt Number	P33316
Molecular Weight	~18 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in A431 and Raji cell lysates. Western Blotting Analysis: 0.5 µg/mL of this antibody detected dUTPase in 10 µg of A431 and Raji cell lysates.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABC608	04055977164053

Documentation

Anti-dUTPase Antibody, clone 6A6.2 分析证书

标题	批号
Anti-dUTPase, clone 6A6.2 - 3472398	3472398
Anti-dUTPase, clone 6A6.2 -Q2564178	Q2564178

技术信息

标题
White Paper: Further considerations of antibody validation and usage.

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描述

ABC457

Anti-dUTPase Antibody

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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