数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABF62 Sigma-AldrichAnti-Tim3 Antibody, clone 2E2

Anti-Tim3 Antibody, clone 2E2 detects level of Tim3 & has been published & validated for use in WB, FC.

Anti-Tim3 Antibody, clone 2E2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考

Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: HAVCR2, TIM3, TIMD3 UniProt Number: Q8TDQ0

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, FC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABF62
Description	Anti-Tim3 Antibody, clone 2E2
Alternate Names	Hepatitis A virus cellular receptor 2 homolog T-cell immunoglobulin and mucin domain-containing protein 3 T-cell membrane protein 3 TIMD-3 TIM-3
Background Information	As a member of the T cell immunoglobulin and mucin domain (TIM) family, Tim-3 is reported to promote or terminate Th1 immunity and is thought to influence a range of inflammatory conditions. It is constitutively expressed in a subset of murine IFNgamma-secreting Th1 cells, but not Th2 cells, in both human and mice. Additionally, Tim-3 is expressed dendritic cells, and by a subset of CD4+ cells where its levels of expression increase upon anti-CD3/28 stimulation. This molecule is also highly expressed in in vitro polarized Th1 cells, and at lower levels in Th17 cells. It is known to synergize with Toll-like receptors and is thought to regulate Th1 and Th17 cytokine secretion.

References

Product Information
Format	Purified
Control	Human thymus tissue lysate
Presentation	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-Tim3 Antibody, clone 2E2 detects level of Tim3 & has been published & validated for use in WB, FC.
Key Applications	Western Blotting Flow Cytometry
Application Notes	Flow Cytometry Analysis: A 1:1,000 dilution of this antibody detected Tim3 in human monocyte derived dendritic cells.

Biological Information
Immunogen	Recombinant protein corresponding to human Tim3.
Clone	2E2
Host	Mouse
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_116171
Entrez Gene Summary	CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Gene Symbol	HAVCR2 TIM3 TIMD3
Purification Method	Protein G Purified
UniProt Number	Q8TDQ0
UniProt Summary	FUNCTION: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Molecular Weight	~30 kDa observed.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in human thymus tissue lysate. Western Blot Analysis: A 1:2,000 dilution of this antibody detected Tim3 in human thymus tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABF62	04053252591327

Documentation

Anti-Tim3 Antibody, clone 2E2 MSDS

职位
物料安全数据表 (MSDS)

Anti-Tim3 Antibody, clone 2E2 分析证书

标题	批号
Anti-Tim3, clone 2E2 - 2373432	2373432
Anti-Tim3, clone 2E2 - 2394109	2394109
Anti-Tim3, clone 2E2 - 2420526	2420526
Anti-Tim3, clone 2E2 - 2318833	2318833
Anti-Tim3, clone 2E2 - 2505471	2505471
Anti-Tim3, clone 2E2 - 2906340	2906340
Anti-Tim3, clone 2E2 - 3532430	3532430
Anti-Tim3, clone 2E2 - NRG1906479	NRG1906479
Anti-Tim3, clone 2E2 -2527586	2527586
Anti-Tim3, clone 2E2 -2568153	2568153

参考

参考概述	公共医疗ID
Validation and comparison of tumor-associated trypsin inhibitor (TATI) immunoassays. Elisabete Janeiro,Joana Guimarães,Ulf-Håkan Stenman,Manuela Catarino,Outi Itkonen,Joana Guimar,Ulf-H Stenman Clinica chimica acta; international journal of clinical chemistry 413 2012 显示摘要 Tumor-associated trypsin inhibitor (TATI) is mainly proposed as a tumor marker for ovarian cancer. However, recent discoveries of TATI in cancer and inflammatory diseases show that assay of TATI in biological samples is of increasing interest.	22507084

参考概述

公共医疗ID

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

此产品已添加到您的购物车。