数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

610205 Sigma-AldrichAnti-Tie2 Mouse mAb (Ab33)

This Anti-Tie2 Mouse mAb (Ab33) is validated for use in Frozen Sections, Immunoblotting, Immunoprecipitation, Paraffin Sections for the detection of Tie2.

Anti-Tie2 Mouse mAb (Ab33) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Anti-Angiopoietin Receptor, Anti-Tek

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概述

Replacement Information

重要规格表

Species Reactivity	Host	Antibody Type
H, M, Porcine, R	M	Monoclonal Antibody

价格及供货情况

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Description
Overview	Recognizes the ~140-45 kDa Tie2 protein.
Catalogue Number	610205
Brand Family	Calbiochem®
Synonyms	Anti-Angiopoietin Receptor, Anti-Tek

References
References	Lin, P., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 8829. Wong, A.L., et al. 1997. Circ. Res. 81, 567. Peters, K.G., et al. 1998. Br. J. Cancer 77, 51.

Product Information
Form	Liquid
Formulation	In 150 mM NaCl, 100 mM Tris-glycine, 30% glycerol, pH 7.4.
Preservative	≤0.1% sodium azide
Quality Level	MQ100

Applications
Key Applications	Frozen Sections Immunoblotting (Western Blotting) Immunoprecipitation Not Paraffin Sections
Application Notes	Frozen Sections (see comments) Immunoblotting (0.2-1 µg/ml, chemiluminescence) Immunoprecipitation (see comments) Paraffin Sections (not recommended)
Application Comments	For frozen sections, tissues were treated with Triton^®-X-100 detergent. This antibody has also been reported to work for immunoprecipitation. Variables associated with assay conditions will dictate the proper working dilution.

Biological Information
Immunogen	a recombinant protein consisting of amino acids 1-745 of human Tie2 fused to a His•Tag^® sequence
Immunogen	Human
Clone	Ab33
Host	Mouse
Isotype	IgG₁
Species Reactivity	Human Mouse Porcine Rat
Antibody Type	Monoclonal Antibody
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	-20°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
610205-50UGCN	04055977264197

Documentation

Anti-Tie2 Mouse mAb (Ab33) MSDS

职位
物料安全数据表 (MSDS)

Anti-Tie2 Mouse mAb (Ab33) 分析证书

标题	批号
610205	输入批号

参考

参考信息概述
Lin, P., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 8829. Wong, A.L., et al. 1997. Circ. Res. 81, 567. Peters, K.G., et al. 1998. Br. J. Cancer 77, 51.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-November-2017 JSW
Synonyms	Anti-Angiopoietin Receptor, Anti-Tek
Application	Frozen Sections (see comments) Immunoblotting (0.2-1 µg/ml, chemiluminescence) Immunoprecipitation (see comments) Paraffin Sections (not recommended)
Description	Protein G purified mouse monoclonal antibody. Recognizes the ~140-145 kDa Tie2 protein.
Background	Angiopoietin-1 and its naturally occurring inhibitor, angiopoietin-2, exert their effects by inducing autophosphorylation of their signaling receptor Tie2. Phosphorylation of the receptor occurs during vasculogenesis and is required for its activity in regulating endothelial cell proliferation, differentiation and guiding the proper patterning of endothelial cells during blood vessel formation. Tie-2 is a transmembrane receptor-tyrosine kinase that is expressed by endothelial cells and primitive hematopoietic tissues. Tie2/Tek has been shown to be critical for endothelial cell survival, which is evidenced in part by the constitutive phosphorylation that is observed in quiescent endothelium. More recently a multifunction docking site has been identified on the receptor (Tyr¹¹⁰⁰) that serves as a binding site for other partners including Grb2, Grb7, and p85 and acting via an SH2 domain interaction.
Host	Mouse
Immunogen species	Human
Immunogen	a recombinant protein consisting of amino acids 1-745 of human Tie2 fused to a His•Tag^® sequence
Clone	Ab33
Isotype	IgG₁
Species	human, mouse, porcine, rat
Form	Liquid
Formulation	In 150 mM NaCl, 100 mM Tris-glycine, 30% glycerol, pH 7.4.
Concentration Label	Please refer to vial label for lot-specific concentration
Preservative	≤0.1% sodium azide
Comments	For frozen sections, tissues were treated with Triton^®-X-100 detergent. This antibody has also been reported to work for immunoprecipitation. Variables associated with assay conditions will dictate the proper working dilution.
Storage	Avoid freeze/thaw -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Standard Handling
References	Lin, P., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 8829. Wong, A.L., et al. 1997. Circ. Res. 81, 567. Peters, K.G., et al. 1998. Br. J. Cancer 77, 51.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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