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MABC786 Sigma-AldrichAnti-TSG101, clone 4A10 Antibody

Anti-TSG101, clone 4A10 Antibody is an antibody against TSG101, clone 4A10 for use in Western Blotting, Immunohistochemistry, ELISA.

Anti-TSG101, clone 4A10 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TSG101 UniProt Number: Q99816

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB, IHC, ELISA	M	Affinity Purified	Monoclonal Antibody

Description
Catalogue Number	MABC786
Description	Anti-TSG101, clone 4A10 Antibody
Alternate Names	Tumor susceptibility gene 101 protein TSG101 ESCRT-I complex subunit TSG101
Background Information	Tumor susceptibility gene 101 protein (TSG101), also known as ESCRT-I complex subunit TSG101, refers to a series of cytosolic protein complexes that are needed for the proper recognition and sorting of ubiquitin modified carrier proteins into the internal vesicles of the things like endosomes, and other multivesicular bodies (MVBs). TSG101 binds to the ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into MVBs. TSG101 also mediates the association between the ESCRT-0 and ESCRT-I complex in the passage of ubiquitin cargo proteins along the chain of ESCRTs. TSG101 interacts with a protein called stathmin, a cytoplasmic phosphoprotein that is implicated in tumorigenesis, and normal TSG101 appears to act as a negative regulator of growth, genetic stability and cell cycle regulation. Mutations and alternatively spliced mutants are associated with breast and other cancers suggesting that defects in TSG101 assist in tumorigenesis and progression.

References

Product Information
Format	Affinity Purified
Presentation	Purified mouse monoclonal containing PBS, pH 7.4.
Quality Level	MQ100

Applications
Application	Anti-TSG101, clone 4A10 Antibody is an antibody against TSG101, clone 4A10 for use in Western Blotting, Immunohistochemistry, ELISA.
Key Applications	Western Blotting Immunohistochemistry ELISA
Application Notes	Immunohistochemistry Analysis (IHP): A 1:100 dilution from a representative lot detected TSG101 in colon carcinoma tissue. ELISA: The specificity of a representative lot was confirmed by ELISA analysis.

Biological Information
Immunogen	TSG101 protein expressed in E. coli.
Clone	4A10
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG1
Species Reactivity	Human Mouse
Species Reactivity Note	Human, Mouse, (H, M)
Antibody Type	Monoclonal Antibody
Gene Symbol	TSG101
Purification Method	Protein G Purified
UniProt Number	Q99816
Molecular Weight	~48 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in HeLa, NIH/3T3, JC, C2C12 , HEK293, A431 and BCL-1 cell lysates. Western Blotting Analysis (WB): A 1:500-1,000 dilution of this antibody detected TSG101 in HeLa, NIH/3T3, JC, C2C12 , HEK293, A431 and BCL-1 cell lysates.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Storage and Shipping Information

Storage Conditions

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABC786	04055977350296

Documentation

Anti-TSG101, clone 4A10 Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-TSG101, clone 4A10 Antibody 分析证书

标题	批号
Anti-TSG101, clone 4A10 - VP1902153	VP1902153
Anti-TSG101, clone 4A10 -QVP1510298	QVP1510298
Anti-TSG101, clone 4A10 -VP1610063	VP1610063
Anti-TSG101, clone 4A10 Monoclonal Antibody	VP1808100
Anti-TSG101, clone 4A10 Monoclonal Antibody	VP1708043
Anti-TSG101, clone 4A10 Monoclonal Antibody	VP1803023

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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