数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

ABC926 Sigma-AldrichAnti-TRIM11 Antibody

Detect TRIM11 using this rabbit polyclonal Anti-TRIM11 Antibody, Cat. No. ABC926, validated for use in Western Blotting and Immunohistochemistry (Paraffin).

Anti-TRIM11 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
技术信息

Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TRIM11, RNF92 UniProt Number: Q96F44

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB, IH(P)	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	ABC926
Description	Anti-TRIM11 Antibody
Alternate Names	E3 ubiquitin-protein ligase TRIM11 Protein BIA1 RING finger protein 92 Tripartite motif-containing protein 11 TRIM11
Background Information	E3 ubiquitin-protein ligase TRIM11 (UniProt Q96F44; also known as Protein BIA1, RING finger protein 92, Tripartite motif-containing 11, Tripartite motif-containing protein 11) is encoded by the TRIM11 (also known as BIA1, RNF92) gene (Gene ID 81559) in human. TRIM11 belongs to a family of more than 70 TRIM/RBCC proteins characterized by their shared tripartite motif structure, also known as the RBCC (RING finger, B-box, and coiled-coil) domain. The B-box and coiled coil regions are believed to participate in protein-protein interactions and formation of macromolecular complexes. TRIM proteins are involved in diverse cellular processes, including cell proliferation, differentiation, oncogenesis, and apoptosis. The presence of a RING domain suggests that TRIM proteins function as E3 ubiquitin ligases. The neuroprotective peptide humanin, activator-recruited cofactor (ARC) 105-kDa component (ARC105), the transcription factors Pax6 and PHOX2B are all known subrates targeted by TRIM11-mediated degradation through the ubiquitin-proteasome system. In addition, TRIM11 is also reported to interfere with the early steps of HIV-1 replication in host cells in a RING domain-dependent manner.

References

Product Information
Format	Affinity Purified
Presentation	Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect TRIM11 using this rabbit polyclonal Anti-TRIM11 Antibody, Cat. No. ABC926, validated for use in Western Blotting and Immunohistochemistry (Paraffin).
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected TRIM11 in human prostate cancer, human colon cancer, human melanoma, and human kidney tissue.

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to human TRIM11.
Concentration	Please refer to lot specific datasheet.
Host	Rabbit
Specificity	This antibody is expected to react with all three spliced isoforms of human TRIM11.
Species Reactivity	Human Mouse
Species Reactivity Note	Human, Mouse. Predicted to react with Rhesus Macaque, Canine based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_660215
Gene Symbol	TRIM11 RNF92
Purification Method	Affinity Purfied
UniProt Number	Q96F44
Molecular Weight	~53 kDa observed. 52.8 kDa (isoform 1), 43.0 kDa (isoform 2), and 52.6 kDa (isoform 3) calculated.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in murine macrophage RAW264.7 cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected TRIM11 in 10 µg of murine macrophage RAW264.7 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABC926	04055977176872

Documentation

Anti-TRIM11 Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-TRIM11 Antibody 分析证书

标题	批号
Anti-TRIM11 - 3260185	3260185
Anti-TRIM11 - 3336231	3336231
Anti-TRIM11 - 3874240	3874240
Anti-TRIM11 - 3926616	3926616
Anti-TRIM11 - 4013904	4013904
Anti-TRIM11 - 4158991	4158991
Anti-TRIM11 -Q2583322	Q2583322

技术信息

标题
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

此产品已添加到您的购物车。