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AB9712 Sigma-AldrichAnti-Sortilin Antibody

Anti-Sortilin Antibody is an antibody against Sortilin for use in WB, IH.

Anti-Sortilin Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
数据表

Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: SORT1, NT3, Gp95, NTR3 UniProt Number: Q99523

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概述

Replacement Information

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R	WB, IHC	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	AB9712
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Sortilin Antibody
Alternate Names	Neurotensin receptor 3
Background Information	Neurotensin receptor 3 or sortilin (the intracellular sorting protein 95 kDa) is a member of a family of receptors characterized by a single transmembrane domain, a short intracytoplasmic domain, and a long cysteine-rich luminal extracellular domain. This receptor has been found in the brain, spinal cord, muscle and other peripheral cell types, and in cancer cells. Sortilin exhibits sequence similarities with proteins involved in intracellular transport and trafficking.

References

Product Information
Format	Serum
Presentation	Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material.
Quality Level	MQ100

Applications
Application	Anti-Sortilin Antibody is an antibody against Sortilin for use in WB, IH.
Key Applications	Western Blotting Immunohistochemistry
Application Notes	Western blot: 1:1,000-1:2,000 on extracts from NSC34 cells. Immunohistochemistry: 1:500-1:1,000 on rat spinal cord. Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	Recombinant protein from the extracellular domain of human sortilin.
Host	Rabbit
Specificity	Sortilin (Neurotensin receptor 3). By Western blot the antibody recognizes a strong band at ~90 kDa in extracts of NSC34 cells. By immunohistochemistry the antibody intensely stains motor neurons within the rat spinal cord.
Species Reactivity	Human Mouse Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_002959.4
Entrez Gene Summary	This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
Gene Symbol	SORT1 NT3 Gp95 NTR3
Purification Method	Serum
UniProt Number	Q99523
UniProt Summary	FUNCTION: SwissProt: Q99523 # Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. SIZE: 831 amino acids; 92068 Da SUBUNIT: Interacts with LPL and SLC2A4 (By similarity). Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP, GM2A and PSAP. Forms a complex with NGFR which binds specifically to the precursor forms of NGFB (proNGFB) and BDNF (proBDNF). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.TISSUE SPECIFICITY: Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver. DOMAIN: SwissProt: Q99523 The N-terminal propeptide may facilitate precursor transport within the Golgi stack. Intrachain binding of the N- terminal propeptide and the extracellular domain may also inhibit premature ligand binding. & The extracellular domain may be shed following protease cleavage in some cell types. PTM: The N-terminal propeptide is cleaved by furin and possibly other homologous proteases. & Contains 8 intrachain disulfide bonds. & N-glycosylated. SIMILARITY: Contains 9 BNR repeats.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain lyophilized material at -20 to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (ACS grade or better) can be added 1:1 for additional stability.

Packaging Information
Material Size	50 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
AB9712	04053252286896

Documentation

Anti-Sortilin Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-Sortilin Antibody 分析证书

标题	批号
RABBIT ANTI- SORTILIN POLYCLONAL ANTIBODY - 2115882	2115882
RABBIT ANTI- SORTILIN POLYCLONAL ANTIBODY - 2120008	2120008
RABBIT ANTI- SORTILIN POLYCLONAL ANTIBODY - 2145907	2145907
RABBIT ANTI- SORTILIN POLYCLONAL ANTIBODY - 2384638	2384638
RABBIT ANTI- SORTILIN - 3448830	3448830
RABBIT ANTI- SORTILIN -2604316	2604316
RABBIT ANTI- SORTILIN -2668102	2668102
RABBIT ANTI- SORTILIN POLYCLONAL ANTIBODY	3045108
RABBIT ANTI- SORTILIN POLYCLONAL ANTIBODY - 2007677	2007677
RABBIT ANTI- SORTILIN POLYCLONAL ANTIBODY - 2013927	2013927

参考

参考概述	公共医疗ID
Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system Sarret, P. J. Comp. Neurol., 461:483-505 (2003) 2003	12746864

数据表

标题
RABBIT ANTI- SORTILIN POLYCLONAL ANTIBODY

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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