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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABN390 Sigma-AldrichAnti-Sigma IR Antibody, clone ICR-SIG1R-A

Detect the Sigma IR protein using this Anti-Sigma IR, clone ICR-SIG1R-A validated for use in wb, IP, ICC, Flow & IHC.

Anti-Sigma IR Antibody, clone ICR-SIG1R-A MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: SIGMAR1, OPRS1, SRBP UniProt Number: Q99720

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB, IP, ICC, FC, IHC	R	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN390
Description	Anti-Sigma IR Antibody, clone ICR-SIG1R-A
Alternate Names	Sigma non-opioid intracellular receptor 1 Sigma 1-type opioid receptor Sigma1-receptor Sigma1R
Background Information	Sigma1R, or Sigma non-opioid intracellular receptor 1, is part of the ERG2 family that forms a ternary complex with ANK2 and ITPR3. Sigma1R is involved in lipid transport from the endoplasmic reticulum, BDNF and EGF signaling, potassium ion channel regulation and other cell functions including apoptosis, survival and proliferation. It was initially discovered through its binding to various psychoactive drugs, and has been studied in memory, learning and mood alteration processes. Sigma1R is often found in the nuclear membrane, synapses and endoplasmic reticulum of cells within liver, brain, kidney and thymus tissues.

References

Product Information
Format	Purified
Control	Colo-587 cell lysate
Presentation	Purified rat monoclonal IgG2c in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect the Sigma IR protein using this Anti-Sigma IR, clone ICR-SIG1R-A validated for use in wb, IP, ICC, Flow & IHC.
Key Applications	Western Blotting Immunoprecipitation Immunocytochemistry Flow Cytometry Immunohistochemistry
Application Notes	Immunoprecipitation Analysis: A representative lot was used by an an independent laboratory to detect Sigma IR in certain cancer cell lysates. Immunocytochemistry Analysis: A representative lot was used by an independent laboratory to detect Sigma IR in human cancer cells including pancreatic carcinoma and sarcoma cell lines and xenografts. Flow Cytometry Analysis: A representative lot was used by an an independent laboratory to detect Sigma IR in tumor cells. Immunohistochemistry Analysis: A representative lot was used by an an independent laboratory to detect Sigma IR in human cancer cells including pancreatic carcinoma and sarcoma cell lines and xenografts.

Biological Information
Immunogen	Linear peptide corresponding to human Sigma IR.
Clone	ICR-SIG1R-A
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rat
Isotype	IgG2c
Species Reactivity	Human Mouse
Species Reactivity Note	Demonstrated to react with Human. Predicted to react with Mouse based upon immunogen design.
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_005857
Gene Symbol	SIGMAR1 OPRS1 SRBP
Purification Method	Protein G Purified
UniProt Number	Q99720
Molecular Weight	~25 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing at ~25 kDa, ~23 kDa, ~21.5 kDa, ~12 kDa and ~21 kDa.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in colo-587 cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected Sigma IR in 10 µg of colo-587 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN390	04053252855573

Documentation

Anti-Sigma IR Antibody, clone ICR-SIG1R-A MSDS

职位
物料安全数据表 (MSDS)

Anti-Sigma IR Antibody, clone ICR-SIG1R-A 分析证书

标题	批号
Anti-Sigma IR, clone ICR-SIG1R-A - Q2139341	Q2139341
Anti-Sigma IR, clone ICR-SIG1R-A - 2561729	2561729
Anti-Sigma IR, clone ICR-SIG1R-A - 3221966	3221966
Anti-Sigma IR, clone ICR-SIG1R-A - 3291280	3291280
Anti-Sigma IR, clone ICR-SIG1R-A - 3387600	3387600
Anti-Sigma IR, clone ICR-SIG1R-A - 3482788	3482788
Anti-Sigma IR, clone ICR-SIG1R-A -2548722	2548722
Anti-Sigma IR, clone ICR-SIG1R-A -2608854	2608854
Anti-Sigma IR, clone ICR-SIG1R-A -2712569	2712569
Anti-Sigma IR, clone ICR-SIG1R-A -2743583	2743583

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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