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ABF125 Sigma-AldrichAnti-S100A8/MRP-8 Antibody (Azide Free)

This Anti-S100A8/MRP-8 Antibody (Azide Free) is validated for use in Western Blotting and Immunohistochemistry and Activity Assay for the detection of S100A8/MRP-8 (Azide Free).

Anti-S100A8/MRP-8 Antibody (Azide Free) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考

Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: S100a8, Caga, Mrp8 UniProt Number: P27005

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB, IHC, ACT	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	ABF125
Description	Anti-S100A8/MRP-8 Antibody (Azide Free)
Alternate Names	Protein S100-A8 Calgranulin-A Chemotactic cytokine CP-10 Leukocyte L1 complex light chain Migration inhibitory factor-related protein 8 MRP-8 p8 Pro-inflammatory S100 cytokine S100 calcium-binding protein A8 S100A8/MRP-8
Background Information	S100A8, also known as Protein S100-A8, Calgranulin-A, Calprotectin L1L subunit, Cystic fibrosis antigen (CFAG), Leukocyte L1 complex light chain, Migration inhibitory factor related protein 8 (MRP-8), p8, S100 calcium binding protein A8, or Urinary stone protein band A, and encoded by the gene S100A8/CAGA/CFAG/MRP8, is an important protein that binds both zinc and calcium and plays an important role in the regulation of inflammatory processes and immune response. Found in complex with its partner S100A9, S100A8 facilitates chemotaxis, fatty acid trafficking, cytoskeleton reorganization, and NAPDPH oxidase activation and other intracellular activities, as well as a host of extracellular induced activities such as extracellular proinflammatory, antimicrobial, oxidant scavenging, and apoptotic activities . Additionally S100A8 can act as a potent autoimmunity amplifier and appears to augment various cancers and their spread when over expressed. S100A8 is widely expressed and used as biomarker in patients with inflammatory diseases and as a cancer marker in multiple forms of cancer.

References

Product Information
Format	Serum
Presentation	Rabbit polyclonal serum without preservatives.
Quality Level	MQ100

Applications
Application	This Anti-S100A8/MRP-8 Antibody (Azide Free) is validated for use in Western Blotting and Immunohistochemistry and Activity Assay for the detection of S100A8/MRP-8 (Azide Free).
Key Applications	Western Blotting Immunohistochemistry Activity Assay
Application Notes	Activity Assay Analysis: A representative lot detected that S100A8/MRP-8 reduces mouse neutrophil accumulation in dorsum-raised air pouchs in the presence of MSU crystals (Ryckman, C., et al. (2003). ARTHRITIS & RHEUMATISM. 48(8):2310–2320). Immunohistochemistry Analysis: A representative lot detected S100A8/MRP-8 in mouse arthritic paw tissue (Cesaro, A., et al. (2012). PLOS ONE. 7(9):e4578).

Biological Information
Immunogen	Recombinant protein corresponding to mouse S100A8/MRP-8.
Host	Rabbit
Species Reactivity	Human Mouse
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_038678
Gene Symbol	S100a8 Caga Mrp8
Purification Method	Unpurified
UniProt Number	P27005
Molecular Weight	~10 kDa observed. Uncharacterized band(s) may appear in some lysates.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human spleen tissue lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected S100A8/MRP-8 in 10 µg of human spleen tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABF125	04053252983405

Documentation

Anti-S100A8/MRP-8 Antibody (Azide Free) MSDS

职位
物料安全数据表 (MSDS)

Anti-S100A8/MRP-8 Antibody (Azide Free) 分析证书

标题	批号
Anti-S100A8/MRP-8 (Azide Free) - Q2441541	Q2441541
Anti-S100A8/MRP-8 (Azide Free) - 3587082	3587082

参考

参考概述	公共医疗ID
Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis. Ryckman, Carle, et al. Arthritis Rheum., 48: 2310-20 (2003) 2003 显示摘要 To examine the role of chemokines, S100A8, and S100A9 in neutrophil accumulation induced by the causative agent of gout, monosodium urate monohydrate (MSU) crystals.	12905486

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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