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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABC112 Sigma-AldrichAnti-RASSF1 Antibody, clone 5C9.1

Detect RASSF1 using this Anti-RASSF1 Antibody, clone 5C9.1 validated for use in western blotting & IHC.

Anti-RASSF1 Antibody, clone 5C9.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: RASSF1, RDA32 UniProt Number: Q9NS23

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IHC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABC112
Replaces	MABE526
Description	Anti-RASSF1 Antibody, clone 5C9.1
Alternate Names	Ras association domain-containing protein 1
Background Information	RASSF1, also known as Ras association domain-containing protein 1, and encoded by the gene RASSF1/RDA32, is an important cell cycle and cell proliferation regulator protein. RASSF1 acts as a tumor suppressor and operates within the death receptor dependent apoptotic pathways. Additionally, RASSF1 inhibits proliferation at the G1/S boundary by regulating the accumulation of cyclin D1 protein. RASSF1 is localized to the cytoplasm and cytoskeleton depending upon cellular environment. RASSF1 localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. The protein also co-localizes with MDM2 in the nucleus. RASSF1 is expressed in multiple isoforms but in generally it is ubiquitously expressed but down regulated in cancer and tumor cells.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect RASSF1 using this Anti-RASSF1 Antibody, clone 5C9.1 validated for use in western blotting & IHC.
Key Applications	Western Blotting Immunohistochemistry
Application Notes	Immunohistochemistry Analysis: A 1:50-500 dilution from a representative lot detected RASSF1 in human kidney and human prostate cancer tissue.

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to human RASSF1.
Clone	5C9.1
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_009113
Gene Symbol	RASSF1 RDA32
Purification Method	Protein G Purified
UniProt Number	Q9NS23
Molecular Weight	~39 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human brain tissue lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected RASSF1 in 10 µg of human brain tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABC112	04053252943195

Documentation

Anti-RASSF1 Antibody, clone 5C9.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-RASSF1 Antibody, clone 5C9.1 分析证书

标题	批号
Anti-RASSF1, clone 5C9.1 - Q2355213	Q2355213

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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