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ABN242 Sigma-AldrichAnti-Pannexin-1/PANX1 Antibody

Anti-Pannexin-1/PANX1 Antibody is an antibody against Pannexin-1/PANX1 for use in Western Blotting, Immunohistochemistry.

Anti-Pannexin-1/PANX1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
小册子

Research Category: Neuroscience Research Sub-Category: Signaling Neuroscience Gene Symbol: PANX1, MRS1, PX1 UniProt Number: Q96RD7

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R	WB, IHC	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	ABN242
Replaces	AB9886
Description	Anti-Pannexin-1/PANX1 Antibody
Alternate Names	Pannexin-1 Innexin
Background Information	Pannexin-1 (UniProt Q96RD7; also known as Innexin) is encoded by the PANX1 (also known as MRS1, PX1) gene (ORF UNQ2529/PRO6028; Gene ID 24145) in human. Pannexin 1 is a high-conductance, voltage-gated channel protein widely expressed in many organs and tissues, including the sensory systems (eye, inner ear, taste buds, and the olfactory epithelium) and both neuronal and non-neuronal cell types. Three pannexin family genes (PANX1-3) have been identified in human and mouse genomes. Pannexin proteins share structural and functional similarities and play important roles in many physiological and pathological processes, such as ATP release, Ca2+ homeostasis, synaptic neurotransmitters release, apoptosis, and immunological response. Pannexin-1 deficiency causes caspase-3 activation and apoptosis induction of hair cells in cochlear spiral limbus (SLM), resulting in hearing loss among Panx1-/- mice. Panx1 is also expressed in the retina, lens and cornea of the eye, where it plays an important role in mediating the crosstalk between immune and neuronal cells. Pannexin-1 channel opening, frequently together with the activation of purinergic receptors by extracellular ATP, is reported to have a great implication in diverse pathological conditions, including ischemia, trauma, HIV infection, inflammation, migraine, and cancer cell growth.

References

Product Information
Format	Affinity Purified
Presentation	Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-Pannexin-1/PANX1 Antibody is an antibody against Pannexin-1/PANX1 for use in Western Blotting, Immunohistochemistry.
Key Applications	Western Blotting Immunohistochemistry
Application Notes	Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Pannexin-1/PANX1 in human testis and mouse kidney tissue sections.

Biological Information
Immunogen	GST-tagged recombinant human Pannexin-1/PANX1 C-terminal fragment.
Epitope	C-terminal
Concentration	Please refer to lot specific datasheet.
Host	Rabbit
Specificity	Expected to react with both spliced isoforms reported by UniProt (Q96RD7-1 & Q96RD7-2).
Species Reactivity	Human Mouse Rat
Species Reactivity Note	Human, Mouse, Rat. Predicted to react with Chimpanzee, Gorilla based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_056183
Gene Symbol	PANX1 MRS1 PX1
Purification Method	Affinity Purfied
UniProt Number	Q96RD7
Molecular Weight	~55 kDa observed. 55-58 kDa (membrane glycosylated) and 43 kDa (cytosolic non-glycosylated) expected. 48.1 kDa (isoform 1) & 47.6 kDa (isoform 2) calculated.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human cortex tissue lysate. Western Blotting Analysis: 0.1 µg/mL of this antibody detected Pannexin-1/PANX1 in 10 µg of human cortex tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABN242	04055977312539

Documentation

Anti-Pannexin-1/PANX1 Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-Pannexin-1/PANX1 Antibody 分析证书

标题	批号
Anti-Pannexin-1/PANX1 - 3423492	3423492
Anti-Pannexin-1/PANX1 - 3584359	3584359
Anti-Pannexin-1/PANX1 - 3686320	3686320
Anti-Pannexin-1/PANX1 - 3764391	3764391
Anti-Pannexin-1/PANX1 - 4144913	4144913
Anti-Pannexin-1/PANX1 -Q2638543	Q2638543
Anti-Pannexin-1/PANX1 Polyclonal Antibody	3150363

小册子

标题
Neuroscience Solutions for productive research

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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