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04-639 Sigma-AldrichAnti-PP2A Antibody, B subunit, B56 delta, clone H5D12

This Anti-PP2A Antibody, B subunit, B56 delta, clone H5D12 is validated for use in WB for the detection of PP2A.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Signaling Research Sub-Category: Kinases & Phosphatases Gene Symbol: PPP2R5D, B56D, MGC2134, MGC8949 UniProt Number: Q14738

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概述

Replacement Information

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	M	Purified	Monoclonal Antibody

Description
Catalogue Number	04-639
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-PP2A Antibody, B subunit, B56 delta, clone H5D12
Background Information	PP2A is a heterotrimeric phosphatase, ccomposed of A, B and C subunits. The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. Three families of B subunits have been identified thus far. The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma . The B' (or B56) family consists of at least seven splice variantsderived from five genes. RNA's for the two members of the B'' family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B' subunits are conserved from yeast to mammals.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG1 antibody in PBS with 0.05% NaN3.
Quality Level	MQ100

Applications
Application	This Anti-PP2A Antibody, B subunit, B56 delta, clone H5D12 is validated for use in WB for the detection of PP2A.
Key Applications	Western Blotting
Application Notes	Immunoblotting (1:500 to 1:2000) Optimal working dilutions must be determined by the end user

Biological Information
Immunogen	GST fusion protein corresponding to the N-terminus of human PP2A, B subunit, B56 delta
Clone	H5D12
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	Human PP2A, B subunit, B56 delta. This monoclonal antibody is the delta isoform for the B56 family of protein phosphatase 2A.
Isotype	IgG1
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_006245
Entrez Gene Summary	The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an delta isoform of the regulatory subunit B56 subfamily.
Gene Symbol	PPP2R5D B56D MGC2134 MGC8949
UniProt Number	Q14738
UniProt Summary	FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. TISSUE SPECIFICITY: Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. INDUCTION: By retinoic acid; in neuroblastoma cell lines. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B56 family.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
04-639	04053252584572

Documentation

Anti-PP2A Antibody, B subunit, B56 delta, clone H5D12 MSDS

职位
物料安全数据表 (MSDS)

Anti-PP2A Antibody, B subunit, B56 delta, clone H5D12 分析证书

标题	批号
Anti- PP2A, B subunit, B56 delta, clone H5D12 - NG1524691	NG1524691
Anti- PP2A, B subunit, B56 delta, clone H5D12 -2765920	2765920
Anti- PP2A, B subunit, B56 delta, clone H5D12 -3167166	3167166
Anti- PP2A, B subunit, B56 delta, clone H5D12 Monoclonal Antibody	2876059
Anti- PP2A, B subunit, B56 delta, clone H5D12_2845536	2845536

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描述

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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