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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABN128 Sigma-AldrichAnti-PITX3 Antibody, clone 12G4.1

Anti-PITX3 Antibody, clone 12G4.1 is an antibody against PITX3 for use in Western Blotting.

Anti-PITX3 Antibody, clone 12G4.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: PITX3, PTX3, ASMD, CTPP4, CTRCT11 UniProt Number: O75364

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概述

Replacement Information

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN128
Description	Anti-PITX3 Antibody, clone 12G4.1
Alternate Names	Pituitary homeobox 3 Homeobox protein PITX3 Paired-like homeodomain transcription factor 3
Background Information	Pituitary homeobox 3 (UniProt O75364; also known as Homeobox protein PITX3, Paired-like homeodomain transcription factor 3) is encoded by the PITX3 (also known as ASMD, CTPP4, CTRCT11, PTX3) gene (Gene ID 5309) in human. PITX3 is a bicoid-related homeodomain transcription factor critical for the development of the ocular lens, mesencephalic dopaminergic neurons and skeletal muscle. PITX3 exerts its developmental impact on dopaminergic neurons by directly regulating the expression of a cascade of downstream genes, including TH, VMAT2, DAT, BDNF, and GDNF. PITX3 and the related PITX2 are both key regulators of intracellular redox state and play an important role in preventing DNA damage during fetal myogenesis. Human PITX3 gene mutations are linked to cataracts and anterior segment abnormalities and PITX3 polymorphisms are associated with Parkinson's disease. In aphakia (ak) mice, deletions in the Pitx3 promoter region cause abnormal lens development.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-PITX3 Antibody, clone 12G4.1 is an antibody against PITX3 for use in Western Blotting.
Key Applications	Western Blotting

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to a sequence within the N-terminal region of human PITX3.
Epitope	N-terminal region.
Clone	12G4.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG2aκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_005020
Gene Symbol	PITX3 PTX3 ASMD CTPP4 CTRCT11
Purification Method	Protein G Purified
UniProt Number	O75364
Molecular Weight	~32 kDa observed. Uncharacterized band(s) may appear in some lysates.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human retinoblastoma Y79 cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected PITX3 in 10 µg of human retinoblastoma Y79 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN128	04055977329452

Documentation

Anti-PITX3 Antibody, clone 12G4.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-PITX3 Antibody, clone 12G4.1 分析证书

标题	批号
Anti-PITX3, clone 12G4.1 -Q2649795	Q2649795

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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