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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABF261 Sigma-AldrichAnti-PD-1 Antibody, clone 16A2.1

Anti-PD-1 Antibody, clone 16A2.1 is an antibody against PD-1 for use in Western Blotting, Flow Cytometry.

Anti-PD-1 Antibody, clone 16A2.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
技术信息

Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: PDCD1, PD1 UniProt Number: Q15116

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, FC	M	Affinity Purified	Monoclonal Antibody

Description
Catalogue Number	MABF261
Description	Anti-PD-1 Antibody, clone 16A2.1
Alternate Names	PD-1 Programmed cell death protein 1 Protein PD-1 hPD-1 CD279
Background Information	Programmed cell death protein 1 (PD-1) (UniProt Q15116), also known as CD279, hPD-1, hPD-I, hSLE1, Protein PD-1, Systemic lupus erythematosus susceptibility 2) is a type I single transmembrane protein encoded by the PDCD1 gene in human. Maintenance of peripheral tolerance by preventing the development of autoimmunity due to T lymphocytes specific for self-antigens is essential for homeostasis of the immune system. PD-1 receptor CD279 and its ligands PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC; CD273) play a vital role in the induction and maintenance of peripheral tolerance. Upregulated PD-1 expression is seen on conventional CD4+ CD25- T cells (Tconv) when exposed to mesenchymal stem cells, resulting in increased Tconv apoptosis due to PD-1 stimulation by the MSC PD-L2.

References

Product Information
Format	Affinity Purified
Presentation	Purified mouse monoclonal IgG2ak in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-PD-1 Antibody, clone 16A2.1 is an antibody against PD-1 for use in Western Blotting, Flow Cytometry.
Key Applications	Western Blotting Flow Cytometry
Application Notes	Flow Cytometry Analysis: 2.0 µg of this antibody from a representative lot detected PD-1 in 1X10E6 Staph enterotoxin B treated human peripheral blood mononuclear cells.

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to the extracellular domain of human PD-1.
Epitope	Extracellular domain
Clone	16A2.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG2aκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_005009
Gene Symbol	PDCD1 PD1
Purification Method	Protein G Purified
UniProt Number	Q15116
Molecular Weight	~32 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in TPA/LPS treated THP-1 cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected PD-1 in 10 µg of TPA/LPS treated THP-1 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABF261	04055977168280

Documentation

Anti-PD-1 Antibody, clone 16A2.1 分析证书

标题	批号
Anti-PD-1, clone 16A2.1 - 3478265	3478265
Anti-PD-1, clone 16A2.1 - 4082281	4082281
Anti-PD-1, clone 16A2.1 -Q2569101	Q2569101
Anti-PD-1, clone 16A2.1 Monoclonal Antibody	2929105
Anti-PD-1, clone 16A2.1 Monoclonal Antibody	3009966

技术信息

标题
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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