数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABN609 Sigma-AldrichAnti-OCRL/INPP5b Antibody, clone N166A/26

Detect Inositol polyphosphate 5-phosphatase OCRL-1 using this mouse monoclonal antibody, Anti-OCRL/INPP5b Antibody, clone N166A/26 validated for use in western blotting & IHC.

Anti-OCRL/INPP5b Antibody, clone N166A/26 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: OCRL, INPP5F, OCRL1 UniProt Number: Q01968

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, R	WB, IHC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN609
Description	Anti-OCRL/INPP5b Antibody, clone N166A/26
Alternate Names	Inositol polyphosphate 5-phosphatase OCRL-1 Lowe oculocerebrorenal syndrome protein
Background Information	Inositol polyphosphate 5-phosphatase OCRL-1 (ORCL) is also called Lowe oculocerebrorenal syndrome protein. ORCL is a phosphotase that converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate, as well as inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate. ORCL is involved in primary cilia assembly and may also have a role in lysosomal membrane trafficking. ORCL is expressed in brain, skeletal muscle, heart, kidney, lung, placenta, fibroblasts, retina and the retinal pigment epithelium. OCRL defects can cause Lowe oculocerebrorenal syndrome (OCRL) and Dent disease type 2 (DD2).

References

Product Information
Format	Purified
Control	Rat brain tissue lysate
Presentation	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect Inositol polyphosphate 5-phosphatase OCRL-1 using this mouse monoclonal antibody, Anti-OCRL/INPP5b Antibody, clone N166A/26 validated for use in western blotting & IHC.
Key Applications	Western Blotting Immunohistochemistry
Application Notes	Western Blotting Analysis: 0.5 µg/mL from a representative lot detected OCRL/INPP5b in 10 µg of rat brain tissue lysate. Western Blotting Analysis: A representative lot detected OCRL/INPP5b in COS cell lysates transiently transfected with GFP-tagged OCRL or RFP-tagged INPP5b, and demonstrated a loss of signal in COS cell lysates transiently transfected with untagged Kv2.1 plasmids (Prof. J. Trimmer, University of California, Davis.). Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected OCRL/INPP5b in human cerebellum and human cardiac myocytes.

Biological Information
Immunogen	Recombinant protein corresponding to human OCRL/INPP5b.
Clone	N166A/26
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	Cross-reacts with OCRL/INPP5b (Prof. J. Trimmer, Univerity of California, Davis).
Isotype	IgG1κ
Species Reactivity	Human Rat
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_000267
Gene Symbol	OCRL INPP5F OCRL1
Purification Method	Protein G Purified
UniProt Number	Q01968
Molecular Weight	~104 kDa observed. Uncharacterized band(s) may appear in some lysates.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human brain tissue lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected OCRL/INPP5b in 10 µg of human brain tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN609	04053252915376

Documentation

Anti-OCRL/INPP5b Antibody, clone N166A/26 MSDS

职位
物料安全数据表 (MSDS)

Anti-OCRL/INPP5b Antibody, clone N166A/26 分析证书

标题	批号
Anti-OCRL/INPP5b, clone N166A/26 - Q2211108	Q2211108

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

此产品已添加到您的购物车。