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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABN281 Sigma-AldrichAnti-Numb Antibody, clone 6G10.1

Detect Numb using this Anti-Numb Antibody, clone 6G10.1 validated for use in WB & IC.

Anti-Numb Antibody, clone 6G10.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: NUMB UniProt Number: P49757

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, ICC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN281
Description	Anti-Numb Antibody, clone 6G10.1
Alternate Names	Protein numb homolog h-Numb S171
Background Information	Numb plays a key role in neurogenesis and in cell fate decisions. It maintains self-renewal properties in neural progenitor cells, which are also called radial glial cells (RGCs). It functions through inhibition of Notch signaling. Additionally, it is suggested to mediate local repair in brain ventricular wall damage.

References

Product Information
Format	Purified
Control	A431 cell lysate
Presentation	Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect Numb using this Anti-Numb Antibody, clone 6G10.1 validated for use in WB & IC.
Key Applications	Western Blotting Immunocytochemistry
Application Notes	Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Numb in HeLa and A431 cells.

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to human Numb isoforms 1 and 2.
Clone	6G10.1
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	This antibody recognizes Numb isoforms 1 and 2.
Isotype	IgMκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_001005743
Entrez Gene Summary	The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
Gene Symbol	NUMB
UniProt Number	P49757
UniProt Summary	FUNCTION: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. SUBUNIT STRUCTURE: Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
Molecular Weight	~70 kDa observed. Uniprot describes four isoforms at ~71 kDa (isoform 1), ~66 kDa (isoform 2), ~69 kDa (isoform 3), and ~65 kDa (isoform 4).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in A431 cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected Numb in 10 µg of A431 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN281	04053252437359

Documentation

Anti-Numb Antibody, clone 6G10.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-Numb Antibody, clone 6G10.1 分析证书

标题	批号
Anti-Numb, clone 6G10.1 - 2388374	2388374
Anti-Numb, clone 6G10.1 - 2287226	2287226
Anti-Numb, clone 6G10.1 - 2329827	2329827
Anti-Numb, clone 6G10.1 - 3310673	3310673
Anti-Numb, clone 6G10.1 - Q1972617	Q1972617
Anti-Numb, clone 6G10.1 -2514268	2514268
Anti-Numb, clone 6G10.1 -2807705	2807705
Anti-Numb, clone 6G10.1 Monoclonal Antibody	3046701
Anti-Numb, clone 6G10.1 Monoclonal Antibody	2898928

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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