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AB15510 Anti-Neuroligin 2 Antibody

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AB15510
50 µg  
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      概述

      Replacement Information

      重要规格表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ELISARbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15510
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Neuroligin 2 Antibody
      Background InformationNeuroligins are Type I membrane proteins enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. They have been characterized as neuronal cell surface proteins and are thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. They play a major role in the formation or maintenance of synaptic junctions. They are also thought to be involved in the specification of excitatory synapses. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses.
      References
      Product Information
      FormatPurified
      PresentationLiquid in PBS with 0.1% BSA.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Neuroligin 2 Antibody is an antibody against Neuroligin 2 for use in WB, ELISA.
      Key Applications
      • Western Blotting
      • ELISA
      Application NotesWestern blot: 1-10 μg/mL using ECL.
      Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 μg/mL
      ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well.
      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide near the C-terminus of human Neuroligin 2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityNeuroligin 2 (NLGN2).
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.
      Gene Symbol
      • NLGN2
      • KIAA1366
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8NFZ4 # Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures.
      SIZE: 835 amino acids; 90820 Da
      SUBUNIT: Interacts with neurexin 1-beta, neurexin 2-beta and neurexin 3-beta. Interacts with INADL (By similarity). Probably interacts through its C-terminus with DLG4 third PDZ domain.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
      SIMILARITY: SwissProt: Q8NFZ4 ## Belongs to the type-B carboxylesterase/lipase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      AB15510 04053252476501