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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABN1728 Sigma-AldrichAnti-Navbeta2 Antibody, clone N395/68

Detect Navbeta2 using this Anti-Navbeta2 Antibody, clone N395/68 validated for use in Western Blotting, Immunohistochemistry.

Anti-Navbeta2 Antibody, clone N395/68 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书

Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: Scn2b, Gm183, AI840361 UniProt Number: Q56A07

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概述

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特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R, M	WB, IHC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN1728
Description	Anti-Navbeta2 Antibody, clone N395/68
Alternate Names	Sodium channel subunit beta-2 Navbeta2 Sodium channel, voltage-gated, type II, beta polypeptide
Background Information	Sodium channel subunit beta-2 (UniProt Q56A07; also known as Navbeta2, Sodium channel, voltage-gated, type II, beta polypeptide) is encoded by the Scn2b (also known as Gm183, AI840361, 2810451E09Rik) gene (Gene ID 72821) in murine species. Sodium channels are integral plasma membrane proteins that conduct Na+ transport across the plasma membrane. They are classified as either voltage-gated or ligand-gated based on the nature of the triggering mechanism for channel activation. Voltage-gated sodium channels (VGSCs) are also called voltage-sensitive, voltage-dependent, or Nav channels. VGSCs normally consist of an alpha subunit that forms the ion conducting pore and one to two beta subunits that have several functions including channel gating modulation, although the expression of the alpha subunit alone is sufficient to produce a functional channel. There exist nine known alpha subunits (Nav1.1 through Nav1.5 encoded by SCN1A through SCN5A and Nav1.6 through Nav1.9 encoded by SCN8A through SCN11A) and four beta subunits (Navbeta1 through Navbeta4 encoded by SCN1B through SCN4B). Beta 1 and beta 3 interact with the alpha subunit non-covalently, whereas beta 2 and beta 4 associate with alpha via disulfide bond. Beta subunits are members of the Ig superfamily and contain a prototypic V-set Ig loop in their extracellular domain. Beta subunits share no homology with their counterparts of calcium and potassium channels, instead are homologous to neural cell adhesion molecules (CAMs) and the family of L1 CAMs. Navbeta2 is initially produced with a signal peptide sequence (a.a. 1-29), the remmoval of which yields the mature protein with an Ig-like C2-type extracellular domain (a.a. 30-159), a transmembrane segment (a.a. 160-180), and a small cytoplamic tail (a.a. 181-215).

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect Navbeta2 using this Anti-Navbeta2 Antibody, clone N395/68 validated for use in Western Blotting, Immunohistochemistry.
Key Applications	Western Blotting Immunohistochemistry
Application Notes	Western Blotting Analysis: 2.0 µg/mL from a representative lot detected Navbeta2 in 10 µg of rat brain tissue lysate. Immunohistochemistry Analysis: A representative lot detected Navbeta2 immunoreactivity in adult rat hippocampus sections (Courtesy of Professor. James S. Trimmer, UC Davis, CA, USA). Western Blotting Analysis: A representative lot detected Navbeta2 only in brain lysates from wild-type rats and mice, but not in brain lysates from Scn2b-knockout mice.

Biological Information
Immunogen	Recombinant full-length mouse Navbeta2.
Clone	N395/68
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Clone N395/68 detects the sodium channel subunit beta-2 (Navbeta2) target band only in brain lysates from wild-type rats and mice, but not brain lysates from Scn2b-knockout mice. Clone N395/68 does not cross-reacts with Navbeta1, Navbeta3 or Navbeta4.
Isotype	IgG2bκ
Species Reactivity	Rat Mouse
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_001014761
Gene Symbol	Scn2b Gm183 AI840361
Purification Method	Protein G Purified
UniProt Number	Q56A07
Molecular Weight	~38 kDa observed. Target band size appears larger than the calculated molecular weight of 24.23 kDa due to glycosylation.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in mouse brain tissue lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected Navbeta2 in mouse brain tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN1728	04055977315806

Documentation

Anti-Navbeta2 Antibody, clone N395/68 分析证书

标题	批号
Anti-Navbeta2, clone N395/68 - 4081593	4081593
Anti-Navbeta2, clone N395/68 -Q2648341	Q2648341

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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