数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

444105 Sigma-AldrichAnti-Mannose 6-Phosphate Receptor Mouse mAb (2G11)

This Anti-Mannose 6-Phosphate Receptor Mouse mAb (2G11) is validated for use in Immunoblotting, IF, IHC, IP for the detection of Mannose 6-Phosphate Receptor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Recommended Products

概述

Replacement Information

重要规格表

Species Reactivity	Host	Antibody Type
B, H, Mk	M	Monoclonal Antibody

价格及供货情况

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Description
Overview	Recognizes the ~300 kDa mannose 6-phosphate receptor protein.
Catalogue Number	444105
Brand Family	Calbiochem®

References
References	Dintzis, S., et al. 1994. J. Biol. Chem. 269, 12159. Dintzis, S., and Pfeffer, S. 1990. EMBO J. 9, 77.

Product Information
Form	Liquid
Formulation	In PBS.
Preservative	≤0.1% sodium azide
Quality Level	MQ100

Applications
Key Applications	Immunoblotting (Western Blotting) Immunofluorescence Immunohistochemistry Immunoprecipitation
Application Notes	Immunoblotting (1 µg/ml, non-reducing, see comments) Immunofluorescence (see comments) Immunohistochemistry (2-5 µg/ml) Immunoprecipitation (see comments)
Application Comments	Does not detect MPR in hamster (CHO) cells. Not suitable for immunoblotting using reducing conditions. This antibody has also been reported to work for immunoprecipitation and immunofluorescence. Variables associated with assay conditions will dictate the proper working dilution.

Biological Information
Immunogen	native bovine cation independent (CI)-mannose 6-phosphate receptor
Immunogen	Bovine
Epitope	within the extracelluar domain
Clone	2G11
Host	Mouse
Isotype	IgG_2a
Species Reactivity	Bovine Human Monkey
Antibody Type	Monoclonal Antibody
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	-20°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
444105-100UGCN	04055977205411

Documentation

Anti-Mannose 6-Phosphate Receptor Mouse mAb (2G11) MSDS

职位
物料安全数据表 (MSDS)

Anti-Mannose 6-Phosphate Receptor Mouse mAb (2G11) 分析证书

标题	批号
444105	输入批号

参考

参考信息概述
Dintzis, S., et al. 1994. J. Biol. Chem. 269, 12159. Dintzis, S., and Pfeffer, S. 1990. EMBO J. 9, 77.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-August-2007 RFH
Application	Immunoblotting (1 µg/ml, non-reducing, see comments) Immunofluorescence (see comments) Immunohistochemistry (2-5 µg/ml) Immunoprecipitation (see comments)
Description	Purified mouse monoclonal antibody. Recognizes the mannose 6-phosphate receptor protein.
Background	Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of ~300 kDa cation-independent MPRs. The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPRs is predominantly late endosomes, fewer in the trans Golgi network, and ~10% at cell surface. In addition to its man6P binding activity, MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An ~240 kDa soluble, truncated form of the extracellular domain of MPR has been detected circulating in serum that is capable of binding both ligands.
Host	Mouse
Immunogen species	Bovine
Immunogen	native bovine cation independent (CI)-mannose 6-phosphate receptor
Epitope	within the extracelluar domain
Clone	2G11
Isotype	IgG_2a
Species	bovine, not hamster, human, monkey
Form	Liquid
Formulation	In PBS.
Concentration Label	Please refer to vial label for lot-specific concentration
Preservative	≤0.1% sodium azide
Comments	Does not detect MPR in hamster (CHO) cells. Not suitable for immunoblotting using reducing conditions. This antibody has also been reported to work for immunoprecipitation and immunofluorescence. Variables associated with assay conditions will dictate the proper working dilution.
Storage	Avoid freeze/thaw -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Standard Handling
References	Dintzis, S., et al. 1994. J. Biol. Chem. 269, 12159. Dintzis, S., and Pfeffer, S. 1990. EMBO J. 9, 77.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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