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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABS1204 Sigma-AldrichAnti-M-Ras Antibody, clone 11F7.1

Anti-M-Ras Antibody, clone 11F7.1 is an antibody against M-Ras for use in Western Blotting.

Anti-M-Ras Antibody, clone 11F7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书

Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: MRAS, RRAS3 UniProt Number: O14807

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概述

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABS1204
Description	Anti-M-Ras Antibody, clone 11F7.1
Alternate Names	Ras-related protein M-Ras Ras-related protein R-Ras3
Background Information	Ras-related protein M-Ras (UniProt O14807; also known as Ras-related protein R-Ras3) is encoded by the MRAS (also known as RRAS3) gene (Gene ID 22808) in human. Originally characterized as a protein that is involved in actin filament reorganization-induced microspikes formation, M-Ras is a Ras superfamily member predominantly expressed in brain and less abundantly in skeletal muscle and heart. M-Ras and Ras share several common effector molecules, and M-Ras is reported to mediate NGF-stimulated ERK pathway signaling by activating B-Raf in PC12 cells. Unlike Ras, however, NGF-stimulation of PC12 cells results in a sustained activation of M-Ras, while only a trarnsient activation is observed with Ras. M-Ras is initially produced in a 208-amino acid proform, the 3 amino acids at the C-terminal end (a.a. 206-208) is removed posttranslationally to yield the mature protein.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-M-Ras Antibody, clone 11F7.1 is an antibody against M-Ras for use in Western Blotting.
Key Applications	Western Blotting

Biological Information
Immunogen	GST-tagged recombinant internal fragment from the C-terminal half of human M-Ras.
Epitope	Internal (C-terminal half).
Clone	11F7.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Expected to react with both spliced isoforms reported by UniProt (O14807).
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_001078518
Gene Symbol	MRAS RRAS3
Purification Method	Protein G Purified
UniProt Number	O14807
Molecular Weight	~24 kDa observed. 23.52 kDa (isoform 1) and 15.22 kDa (isoform 2) calculated.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in SHSY-5Y cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected M-Ras in 10 µg of SHSY-5Y cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABS1204	04055977332193

Documentation

Anti-M-Ras Antibody, clone 11F7.1 分析证书

标题	批号
Anti-M-Ras, clone 11F7.1 - 3875536	3875536
Anti-M-Ras, clone 11F7.1 -Q2662536	Q2662536

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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