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数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

ABE498 Sigma-AldrichAnti-Lysine-specific demethylase 7 Antibody

Detect Lysine-specific demethylase 7 using this rabbit polyclonal antibody, Anti-Lysine-specific demethylase 7 Antibody validated for use in western blotting.

Anti-Lysine-specific demethylase 7 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: JHDM1D, KDM7 UniProt Number: Q6ZMT4

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概述

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	ABE498
Description	Anti-Lysine-specific demethylase 7 Antibody
Alternate Names	Lysine-specific demethylase 7 JmjC domain-containing histone demethylation protein 1D
Background Information	Lysine-specific demethylase 7, also known as JmjC domain-containing histone demethylation protein 1D, and encoded by the gene JHDM1D/KDM7/KIAA1718, is an important histone demethylase particularly for brain development. JHDM1D specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. JHDM1D also specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. JHDM1D also demethylates H3K9me2 in absence of H3K4me3 and JHDM1D has activity toward H4K20Me1 only when the nucleosome is used as a substrate and when not the histone octamer is used as substrate. JHDM1D is located in the nucleus and widely expressed but lowered expression is observed in glial cells and lymphoid cells. JHDM1D demonstrates tumor suppression by regulating angiogenesis factors when overexpression under starvation conditions in certain cancers, thus JHDM1D is being examined as a potential anti-cancer target.

References

Product Information
Format	Affinity Purified
Presentation	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect Lysine-specific demethylase 7 using this rabbit polyclonal antibody, Anti-Lysine-specific demethylase 7 Antibody validated for use in western blotting.
Key Applications	Western Blotting

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to human Lysine-specific demethylase 7.
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	This antibody is expected to cross react with two known isoforms of Lysine-specific demethylase 7 based upon immunogen design.
Species Reactivity	Human Mouse
Species Reactivity Note	Demonstrated to react with Human and Mouse. Predicted to react with Canine, Mouse, Rhesus Macaque, Chimpanzee Giant Panda, and Marmoset based upon sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_085150
Gene Symbol	JHDM1D KDM7
Purification Method	Affinity Purfied
UniProt Number	Q6ZMT4
Molecular Weight	~110 kDa observed. Uniprot describes two isoforms at 107 kDa (isoform 1) and 92 kDa (isoform 2).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in HEK293 cell lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Lysine-specific demethylase 7 in 10 µg of HEK293 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABE498	04053252930867

Documentation

Anti-Lysine-specific demethylase 7 Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-Lysine-specific demethylase 7 Antibody 分析证书

标题	批号
Anti-Lysine-specific demethylase 7 - Q2296679	Q2296679

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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