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MABE215 Sigma-AldrichAnti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1

Use Anti-LRH-1 Antibody, clone 1LRH-2E1 (Mouse Monoclonal Antibody) validated in WB, ICC to detect LRH-1 also known as Liver receptor homolog 1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Epigenetics & Nuclear Function Gene Symbol: Nr5a2, Lrh1 UniProt Number: P45448

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	WB, ICC	M	Ascites	Monoclonal Antibody

Description
Catalogue Number	MABE215
Description	Anti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1
Alternate Names	Nuclear receptor subfamily 5 group A member 2 Liver receptor homolog 1 LRH-1 NR5A2
Background Information	Liver receptor homolog 1 (LRH-1, CPF, FTF, PHR-1, FTF, or hB1F) is an orphan nuclear receptor that is highly expressed in the intestines, pancreas, ovary, and liver. LRH-1 is a constitutively active transcription factor with a complex role in many cellular processes which may include lipid metabolism, cell proliferation, development, reproduction, and immunity. LRH-1 may interact with an array of transcriptional coactivators that modulate its activity, among which are the MBF1, SRC, and PGC-1α proteins. In addition, ERK phosphorylation on Ser-238 and Ser-243 also enhances LRH-1 activity. However, LRH-1 is also negatively regulated by several factors. For instance, corepressors such as SHP, DAX-1, and PROX-1, preclude its binding to DNA; and sumoylation promotes its inactivation and sequestration into nuclear bodies. LRH-1 targets many genes including the CYP7A1 and CYP8B1 genes involved in bile synthesis; and Oct4 required for pluripotency in embryonic stem cells. LRH-1 has been implicated in inflammatory bowel disease, and tumor development in the intestines and pancreas.

References

Product Information
Format	Ascites
Control	Mouse pancreas tissue lysate
Presentation	Mouse monoclonal IgG2aλ ascites with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Use Anti-LRH-1 Antibody, clone 1LRH-2E1 (Mouse Monoclonal Antibody) validated in WB, ICC to detect LRH-1 also known as Liver receptor homolog 1.
Key Applications	Western Blotting Immunocytochemistry
Application Notes	Western Blot Analysis: A 1:1,000 dilution from representative lot detected Liver receptor homolog-1 in HepG2 and HeLa cell lysates (M. Oulad, IGBMC, France.). Immunocytochemistry Analysis: A representative lot detected Liver receptor homolog-1 in HepG2 and HeLa cells (M. Oulad, IGBMC, France.).

Biological Information
Immunogen	Linear peptide corresponding to the mouse Liver receptor homolog-1.
Clone	1LRH-2E1
Host	Mouse
Species Reactivity	Mouse
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_109601
Gene Symbol	Nr5a2 Lrh1
Purification Method	Unpurified
UniProt Number	P45448
Molecular Weight	~64 kDa, ~56 kDa, and ~42 kDa observed. This antibody detects three isoforms of Liver receptor homolog-1 as described by Uniprot No. O00482.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in mouse pancreas tissue lysate. Western Blot Analysis: A 1:1,000 dilution of this antibody detected Liver receptor homolog-1 in 10 µg of mouse pancrease tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABE215	04053252522215

Documentation

Anti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1 MSDS

职位
物料安全数据表 (MSDS)

Anti-Liver receptor homolog-1 Antibody, clone 1LRH-2E1 分析证书

标题	批号
Anti-Liver receptor homolog-1, clone 1LRH-2E1 - 2446290	2446290
Anti-Liver receptor homolog-1, clone 1LRH-2E1 - 3193338	3193338
Anti-Liver receptor homolog-1, clone 1LRH-2E1 - Q2020493	Q2020493
Anti-Liver receptor homolog-1,clone 1LRH-2E1 -2695317	2695317

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