数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

437695 Sigma-AldrichAnti-Lipoic Acid Rabbit pAb

This Anti-Lipoic Acid Rabbit pAb is validated for use in ELISA, Frozen Sections, Immunoblotting, Paraffin Sections for the detection of Lipoic Acid.

Anti-Lipoic Acid Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Anti-LA

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概述

Replacement Information

重要规格表

Species Reactivity	Host	Antibody Type
A Broad Range Of Species	Rb	Polyclonal Antibody

价格及供货情况

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Description
Overview	Recognizes native lipoic acid. Does not recognize lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products.
Catalogue Number	437695
Brand Family	Calbiochem®
Synonyms	Anti-LA

References
References	Sasaki, M., et al. 2000. J. Autoimmun. 15, 51. Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53. Patrick. L. 2000. Altern. Med. Rev. 5, 290. Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123. Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.

Product Information
Form	Liquid
Formulation	serum diluted in buffer, 50% glycerol, pH 7.5.
Preservative	None
Quality Level	MQ100

Applications
Key Applications	Enzyme-Linked Immunosorbent Assay Frozen Sections Immunoblotting (Western Blotting) Paraffin Sections
Application Notes	ELISA (1:500-1:1000) Frozen Sections (1:50-1:500) Immunoblotting (1:1000-1:10,000) Paraffin Sections (1:50-1:500)
Application Comments	Does not bind lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products. Useful for assessing whether protein-bound lipoic acids have undergone certain forms of oxidative modification. The presence of protein-bound lipoic acid can be used as a marker for mitochondria. Variables associated with assay conditions will dictate the optimal working dilution.

Biological Information
Immunogen	lipoic acid conjugated to KLH
Host	Rabbit
Isotype	IgG
Species Reactivity	A Broad Range Of Species
Antibody Type	Polyclonal Antibody

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
437695-100ULCN	07790788059934

Documentation

Anti-Lipoic Acid Rabbit pAb MSDS

职位
物料安全数据表 (MSDS)

Anti-Lipoic Acid Rabbit pAb 分析证书

标题	批号
437695	输入批号

参考

参考信息概述
Sasaki, M., et al. 2000. J. Autoimmun. 15, 51. Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53. Patrick. L. 2000. Altern. Med. Rev. 5, 290. Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123. Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-August-2007 RFH
Synonyms	Anti-LA
Application	ELISA (1:500-1:1000) Frozen Sections (1:50-1:500) Immunoblotting (1:1000-1:10,000) Paraffin Sections (1:50-1:500)
Description	Rabbit polyclonal antibody supplied as diluted serum. Recognizes native lipoic acid and lipoic acid covalently attached to proteins.
Background	Lipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. It acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. Protein-bound lipoic acids such as E2 subunits, α-ketoglutarate dehydrogenase, or pyruvate dehydrogenase have been shown to be highly susceptible to free radical-derived oxidative modification. Lipoic acid is able to deactivate both fat and water soluble free radicals and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. It has also shown great promise in the treatment of HIV and in diabetes.
Host	Rabbit
Immunogen	lipoic acid conjugated to KLH
Isotype	IgG
Species	a broad range of species
Form	Liquid
Formulation	serum diluted in buffer, 50% glycerol, pH 7.5.
Preservative	None
Comments	Does not bind lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products. Useful for assessing whether protein-bound lipoic acids have undergone certain forms of oxidative modification. The presence of protein-bound lipoic acid can be used as a marker for mitochondria. Variables associated with assay conditions will dictate the optimal working dilution.
Storage	Avoid freeze/thaw ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).
Toxicity	Standard Handling
References	Sasaki, M., et al. 2000. J. Autoimmun. 15, 51. Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53. Patrick. L. 2000. Altern. Med. Rev. 5, 290. Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123. Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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