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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABT39 Sigma-AldrichAnti-Laminin alpha 5 Antibody, clone 4B12

This Anti-Laminin alpha 5 Antibody, clone 4B12 is validated for use in IH for the detection of Laminin alpha 5.

Anti-Laminin alpha 5 Antibody, clone 4B12 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: LAMA5 UniProt Number: O15230

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	IHC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABT39
Description	Anti-Laminin alpha 5 Antibody, clone 4B12
Alternate Names	laminin, alpha 5 Laminin-15 subunit alpha laminin alpha-5 chain Laminin-11 subunit alpha laminin subunit alpha-5 Laminin-10 subunit alpha, Laminin α5, Lamininα5, Laminin-α5
Background Information	Laminin alpha 5 (α5) is a member of the laminin family of extracellular matrix glycoproteins. Laminin’s are important in cell migration, differentiation and in tumor cell incursion. Research shows that laminin alpha 5 may be an early marker of sexual differentiation. In rat, the laminin alpha 5 chain seems to halt expression in the basement membrane of Sertoli cells when secretion of AMH begins but expression increases two weeks after birth when AMH secretion stops. Laminin alpha 5 shows up early during lung development in mice. It has also been linked to inflammatory cell chemotaxis and metalloproteinase activity and may play a role in creating and sustaining mucosal patterns of the mouse small intestine.

References

Product Information
Format	Purified
Control	Human precancerous colorectal lesion tissue
Presentation	Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-Laminin alpha 5 Antibody, clone 4B12 is validated for use in IH for the detection of Laminin alpha 5.
Key Applications	Immunohistochemistry
Application Notes	Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Laminin alpha 5 in human blood vessels and metastatic colorectal adenocarcinoma tissues.

Biological Information
Immunogen	Laminin purified from human placenta
Clone	4B12
Host	Mouse
Isotype	IgG1λ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_005551
Entrez Gene Summary	Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq].
Gene Symbol	LAMA5
Purification Method	Protein G Purified
UniProt Number	O15230
UniProt Summary	FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. SUBUNIT STRUCTURE: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix › basement membrane. Note: Major component. TISSUE SPECIFICTY: Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver. DOMAIN: Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer. SEQUENCE SIMILARITIES: Contains 22 laminin EGF-like domains. Contains 5 laminin G-like domains. Contains 1 laminin IV type A domain. Contains 1 laminin N-terminal domain. SEQUENCE CAUTION: The sequence CAC22310.1 differs from that shown. Reason: Erroneous gene model prediction.
Molecular Weight	400 kDa calculated

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Immunohistochemistry in human precancerous colorectal lesion tissue. Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Laminin alpha 5 in human precancerous colorectal lesion tissue.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABT39	04053252646126

Documentation

Anti-Laminin alpha 5 Antibody, clone 4B12 MSDS

职位
物料安全数据表 (MSDS)

Anti-Laminin alpha 5 Antibody, clone 4B12 分析证书

标题	批号
Anti-Laminin alpha 5, clone 4B12 - 2147127	2147127
Anti-Laminin alpha 5, clone 4B12 - 2395813	2395813
Anti-Laminin alpha 5, clone 4B12 - 2470509	2470509
Anti-Laminin alpha 5, clone 4B12 - 2207228	2207228
Anti-Laminin alpha 5, clone 4B12 - 2297287	2297287
Anti-Laminin alpha 5, clone 4B12 - 3204240	3204240
Anti-Laminin alpha 5, clone 4B12 - 3483441	3483441
Anti-Laminin alpha 5, clone 4B12 - 3714396	3714396
Anti-Laminin alpha 5, clone 4B12 - NRG1843064	NRG1843064
Anti-Laminin alpha 5, clone 4B12 -2515426	2515426

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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