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AB3270 Anti-K+-Cl- Cotransporter 4 Antibody

Anti-K+-Cl-Cotransporter 4 Antibody is an antibody against K+-Cl-Cotransporter 4 for use in ELISA & WB.

Anti-K+-Cl- Cotransporter 4 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: SLC12A7, KCC4, DKFZP434F076 UniProt Number: Q9Y666
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AB3270
50 µg  
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      概述

      特卖

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      重要规格表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3270
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-K+-Cl- Cotransporter 4 Antibody
      Alternate Names
      • KCC4
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in 100 mM Tris, pH 7.5, containing 0.2% BSA and 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-K+-Cl-Cotransporter 4 Antibody is an antibody against K+-Cl-Cotransporter 4 for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using ECL.

      Approximate size on reduced westerns is 120-140kDa; membrane preparations and proteinase inhibitors are strongly recommended. See protocol under Technical Service as www.chemicon.com.



      ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 16 amino acid peptide within the cytoplasmic, N-terminus of mouse KCC4.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes K+ Cl- Cotransporter-4 (KCC4). The immunogen shows no significant sequence homology with other KCCs or CCC.

      SPECIES REACTIVITIES: The immunogen sequence is 81% homologous with human KCC4. Reactivity with other species has not been confirmed.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC12A7
      • KCC4
      • DKFZP434F076
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y666 # Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
      SIZE: 1083 amino acids; 119106 Da
      SUBUNIT: Homomultimer and heteromultimer with other K-Cl cotransporters (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Detected in muscle, brain, lung, heart and kidney.
      SIMILARITY: SwissProt: Q9Y666 ## Belongs to the SLC12A transporter family.
      MISCELLANEOUS: Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Global Trade Item Number
      产品目录编号 GTIN
      AB3270 04053252589294