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ABC74 Sigma-AldrichAnti-IGPR-1 Antibody

Anti-IGPR-1 antibody is an antibody against IGPR-1 for use in western blotting, ICC & IHC.

Anti-IGPR-1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TMIGD2, IGPR1 UniProt Number: Q96BF3

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R, H	WB, ICC, IHC	Rb	Purified	Polyclonal Antibody

Description
Catalogue Number	ABC74
Description	Anti-IGPR-1 Antibody
Alternate Names	Transmembrane and immunoglobulin domain-containing protein 2 Immunoglobulin and proline-rich receptor 1 IGPR-1
Background Information	IGPR-1 or Immunoglobulin and proline-rich receptor 1, also called Transmembrane and immunoglobulin domain-containing protein 2 and encoded by the human gene TMIGD2/IGPR1 is a widely expressed epithelial and endothelial membrane protein that plays a role in cell-cell interactions, cell migration and angiogenesis. IGPR-1 regulates cellular morphology, homophilic cell aggregation, and cell-cell interaction. IGPR-1 activity also modulates actin stress fiber formation and focal adhesion and reduces cell migration. Silencing of expression of IGPR-1 by small interfering RNA (siRNA) and by ectopic overexpression in endothelial cells showed that IGPR-1 regulates capillary tube formation in vitro, and in B16F melanoma cells engineered to express IGPR-1 displayed extensive angiogenesis in the mouse Matrigel angiogenesis model. Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multiple Src homology 3 (SH3)-containing signaling proteins, including SH3 protein interacting with Nck (SPIN90/WISH), bullous pemphigoid antigen-1, and calcium channel β2.

References

Product Information
Format	Purified
Presentation	Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-IGPR-1 antibody is an antibody against IGPR-1 for use in western blotting, ICC & IHC.
Key Applications	Western Blotting Immunocytochemistry Immunohistochemistry
Application Notes	Western Blotting Analysis: 2 µg/mL from a representative lot detected IGPR-1 in 10 µg of HepG2 cell lysate, human placenta tissue lysate, HUVEC cell lysate, and L9 cell lysate. Western Blotting Analysis: A representative lot from an independent laboratory detected IGPR-1 in IGPR-1 transfected PAE cell lysates (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.). Immunocytochemistry Analysis: A representative lot from an independent laboratory detected IGPR-1 in IGPR-1 transfected PAE cells (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.). Immunohistochemistry Analysis: A representative lot from an independent laboratory detected IGPR-1 in human colon cancer tissues (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).

Biological Information
Immunogen	Linear peptide corresponding to the cytoplasmic domain of the human mature form of IGPR-1.
Epitope	Cytoplasmic domain
Concentration	1 mg/mL
Host	Rabbit
Species Reactivity	Rat Human
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_001162597
Gene Symbol	TMIGD2 IGPR1
Purification Method	Protein A Purfied
UniProt Number	Q96BF3
Molecular Weight	~58 kDa observed. Uniprot describes two isoforms at 31 kDa and 30 kDa. The pre-mature and mature form of this protein may be observed at 32 kDa and 58 kDa (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.). Uncharacterized band(s) may be observed in some cell lysates.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in PC-12 cell lysate. Western Blotting Analysis: 2 µg/mL of this antibody detected IGPR-1 in 10 µg of PC-12 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABC74	04053252970047

Documentation

Anti-IGPR-1 Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-IGPR-1 Antibody 分析证书

标题	批号
Anti-IGPR-1 - Q2399140	Q2399140
Anti-IGPR-1 - 3231896	3231896
Anti-IGPR-1 - 3845005	3845005
Anti-IGPR-1 -2855848	2855848

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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