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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

393207 Sigma-AldrichAnti-HNE-Michael Adducts, Reduced Rabbit pAb

Anti-HNE-Michael Adducts, Reduced, rabbit polyclonal, specifically recognizes chemically reduced amino acid-(4)-HNE adducts. It is validated for use in ELISA, WB & IHC (frozen & paraffin sections).

Anti-HNE-Michael Adducts, Reduced Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Anti-4-Hydroxy-2-noneal Michael Adducts, Reduced

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概述

Replacement Information

重要规格表

Species Reactivity	Host	Antibody Type
A Broad Range Of Species	Rb	Polyclonal Antibody

价格及供货情况

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Description
Overview	Recognizes chemically reduced amino acid-(4)-HNE adducts. Does not recognize non-reduced adducts or reduced modifications arising from malondialdehyde (MDA) and structurally-related alkenes such as trans-2-noneal.
Catalogue Number	393207
Brand Family	Calbiochem®
Synonyms	Anti-4-Hydroxy-2-noneal Michael Adducts, Reduced

References
References	Toyokuni, S., et al. 2000. Antioxid. Redox. Signal 2, 681. Neely, M.D., et al. 1999. J. Neurochem. 72, 2323. Uchida, K., et al. 1995. Biochem. Biophys. Res. Commun. 212, 1068. Uchida, K., et al. 1995. Arch. Biochem. Biophys. 324, 241. Uchida, K., et al. 1994. Biochemistry 33, 12487.

Product Information
Form	Liquid
Formulation	Serum diluted in 50% glycerol, pH 7.5.
Preservative	None
Quality Level	MQ100

Applications
Key Applications	Enzyme-Linked Immunosorbent Assay Frozen Sections Immunoblotting (Western Blotting) Paraffin Sections
Application Notes	ELISA (1:500-1:1000) Immunoblotting (1:1000-1:4000) Frozen Sections (1:50-1:500) Paraffin Sections (1:50-1:500)
Application Comments	Does not bind non-reduced adducts and reduced modifications arising from malondialdehyde (MDA) or structurally-related alkenals such as trans-2-noneal. Does not cross-react with non-reduced amino acid-HNE Michael adducts. Antibody binding requires the presence of the 4-hydroxyl group. Variables associated with assay conditions will dictate the optimal working dilution.

Biological Information
Immunogen	HNE-treated KLH in which 1:1 amino acid-HNE Michael adducts were chemically reduced
Host	Rabbit
Isotype	IgG
Species Reactivity	A Broad Range Of Species
Antibody Type	Polyclonal Antibody

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
393207-100ULCN	04055977212495

Documentation

Anti-HNE-Michael Adducts, Reduced Rabbit pAb MSDS

职位
物料安全数据表 (MSDS)

Anti-HNE-Michael Adducts, Reduced Rabbit pAb 分析证书

标题	批号
393207	输入批号

参考

参考信息概述
Toyokuni, S., et al. 2000. Antioxid. Redox. Signal 2, 681. Neely, M.D., et al. 1999. J. Neurochem. 72, 2323. Uchida, K., et al. 1995. Biochem. Biophys. Res. Commun. 212, 1068. Uchida, K., et al. 1995. Arch. Biochem. Biophys. 324, 241. Uchida, K., et al. 1994. Biochemistry 33, 12487.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-August-2007 RFH
Synonyms	Anti-4-Hydroxy-2-noneal Michael Adducts, Reduced
Application	ELISA (1:500-1:1000) Immunoblotting (1:1000-1:4000) Frozen Sections (1:50-1:500) Paraffin Sections (1:50-1:500)
Description	Rabbit polyclonal antibody supplied as diluted serum. Recognizes, specifically, chemically reduced amino acid-(4)-HNE adducts.
Background	The CNS is enriched in polyunsaturated fatty acids and is therefore particularly vulnerable to lipid peroxidation. 4-Hydroxy-2-noneal (HNE) is one of the major lipid peroxidation products with cytotoxic and mutagenic activity. It reacts with protein residues such as histidine to generate stable Michael adducts. HNE has been shown to inhibit neurite outgrowth and disrupt microtubules and tubulin modification, suggesting it may play a role in Alzheimer's disease.
Host	Rabbit
Immunogen	HNE-treated KLH in which 1:1 amino acid-HNE Michael adducts were chemically reduced
Isotype	IgG
Species	a broad range of species
Form	Liquid
Formulation	Serum diluted in 50% glycerol, pH 7.5.
Preservative	None
Comments	Does not bind non-reduced adducts and reduced modifications arising from malondialdehyde (MDA) or structurally-related alkenals such as trans-2-noneal. Does not cross-react with non-reduced amino acid-HNE Michael adducts. Antibody binding requires the presence of the 4-hydroxyl group. Variables associated with assay conditions will dictate the optimal working dilution.
Storage	Avoid freeze/thaw ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).
Toxicity	Standard Handling
References	Toyokuni, S., et al. 2000. Antioxid. Redox. Signal 2, 681. Neely, M.D., et al. 1999. J. Neurochem. 72, 2323. Uchida, K., et al. 1995. Biochem. Biophys. Res. Commun. 212, 1068. Uchida, K., et al. 1995. Arch. Biochem. Biophys. 324, 241. Uchida, K., et al. 1994. Biochemistry 33, 12487.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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