数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

AB5472-50UL Sigma-AldrichAnti-Glycine Receptor α3 Subunit Antibody

This Anti-Glycine Receptor α3 Subunit Antibody is validated for use in IH for the detection of Glycine Receptor α3 Subunit.

Anti-Glycine Receptor α3 Subunit Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
数据表

Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: GLRA3 UniProt Number: O75311

Recommended Products

概述

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M, R	IHC	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB5472-50UL
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Glycine Receptor α3 Subunit Antibody
Alternate Names	GLRa3

References

Product Information
Format	Affinity Purified
Control	CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
Presentation	Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
Quality Level	MQ100

Applications
Application	This Anti-Glycine Receptor α3 Subunit Antibody is validated for use in IH for the detection of Glycine Receptor α3 Subunit.
Key Applications	Immunohistochemistry
Application Notes	Western blot: 1:200 on rat brain membranes. Immunohistochemistry on rat brain floating sections and mouse brain floating sections (trypsin pretreatment is recommended). Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	A purified peptide corresponding to amino acid residues 355-368 of rat GlyRa3 (Accession P24524).
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	Recognizes Glycine receptor alpha3 (GlyRalpha3) protein. The epitope is not similar to any other known proteins.
Species Reactivity	Mouse Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_001042543.1 NM_006529.2
Gene Symbol	GLRA3
UniProt Number	O75311
UniProt Summary	FUNCTION: SwissProt: O75311 # The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). SIZE: 464 amino acids; 53800 Da SUBUNIT: Pentamer composed of alpha and beta subunits (By similarity). SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely distributed throughout the central nervous system. DOMAIN: SwissProt: O75311 The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics. SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) family. MISCELLANEOUS: The alpha subunit binds strychnine.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Packaging Information
Material Size	50 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
AB5472-50UL	04053252583711

Documentation

Anti-Glycine Receptor α3 Subunit Antibody 分析证书

标题	批号
RABBIT ANTI-GLYCINE RECEPTOR a3 (GlyRa3) -2696619	2696619
RABBIT ANTI-GLYCINE RECEPTOR α3 (GlyRα3) - 4145788	4145788
RABBIT ANTI-GLYCINE RECEPTOR α3 (GlyRα3) -2532320	2532320
RABBIT ANTI-GLYCINE RECEPTOR α3 (GlyRα3) -2644610	2644610
RABBIT ANTI-GLYCINE RECEPTOR α3 (GlyRα3) -3156746	3156746
RABBIT ANTI-GLYCINE RECEPTOR α3 (GlyRα3) AFFINITY PURIFIED POLYCLONAL ANTIBODY	3116892
RABBIT ANTI-GLYCINE RECEPTOR α3 (GlyRα3) AFFINITY PURIFIED POLYCLONAL ANTIBODY	2994766
RABBIT ANTI-GLYCINE RECEPTOR 3 (GlyR3) -2774103	2774103

参考

参考概述	公共医疗ID
The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts Nikolic, Z, et al J Biol Chem, 273:19708-14 (1998) 1998	9677400
Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor Kuhse, J, et al J Biol Chem, 265:22317-20 (1990) 1990	2176214

数据表

标题
RABBIT ANTI-GLYCINE RECEPTOR 3 (GlyR3) AFFINITY PURIFIED POLYCLONAL ANTIBODY

Related Products

产品目录编号

描述

AB15014

Anti-Glycine Receptor α3 subunit Antibody

显示价格及库存情况

Alternative Packsize

产品目录编号

描述

AB5472-200UL

Anti-Glycine Receptor α3 Subunit Antibody

显示价格及库存情况

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

此产品已添加到您的购物车。