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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABT406 Sigma-AldrichAnti-GPVI Antibody, clone 8E9, Capture Antibody

Anti-GPVI Antibody, clone 8E9, Capture Antibody is an antibody against GPVI for use in western blotting & ELISA.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考

Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: GP6 UniProt Number: Q9HCN6

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, ELISA	R	Purified	Monoclonal Antibody

Description
Catalogue Number	MABT406
Replaces	MABT473
Description	Anti-GPVI Antibody, clone 8E9, Capture Antibody
Alternate Names	Platelet glycoprotein VI GPVI Glycoprotein 6
Background Information	Glycoprotein VI (GPVI), or glycoprotein 6 (GP6), is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. GPVI is a collagen receptor involved in collagen-induced platelet adhesion and activation, and may contribute to arterial and venous thrombus formation. GPVI is a membrane glycoprotein that plays a crucial role in platelet procoagulant activity and subsequent thrombin and fibrin formation. GPVI is expressed in megakaryocytes and platelets. The signaling pathway of GPVI involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. It has been shown that bleeding disorders such as Bleeding Disorder Platelet-Type 11 (BDPLT11), a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen, is caused by defects in GPVI.

References

Product Information
Format	Purified
Presentation	Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-GPVI Antibody, clone 8E9, Capture Antibody is an antibody against GPVI for use in western blotting & ELISA.
Key Applications	Western Blotting ELISA
Application Notes	ELISA Assay: A representative lot from an independent laboratory captured recombinant GPVI in a bead-based sandwich immunoassay (Bigalke, B., et al. (2011). Clin Chem. 57(6):898-904.). This antibody should be used in conjunction with Cat. No. MABT418, Anti-GPVI, clone 8A2, Detection Antibody, as an ELISA capture and detection antibody pair.

Biological Information
Immunogen	Recombinant protein corresponding to human GPVI.
Clone	8E9
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rat
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_001242946
Gene Symbol	GP6
Purification Method	Protein G Purified
UniProt Number	Q9HCN6
Molecular Weight	~50 kDa observed. The calculated molecular weight of this protein is 37 kDa. However, a recombinant protein was observed at 50-55 kDa in Western Blotting.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in recombinant human GPV1 glycoprotein. Western Blotting Analysis: 0.5 µg/mL of this antibody detected 0.1 µg of recombinant human GPV1 glycoprotein.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABT406	04053252955242

Documentation

Anti-GPVI Antibody, clone 8E9, Capture Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-GPVI Antibody, clone 8E9, Capture Antibody 分析证书

标题	批号
Anti-GPVI, clone 8E9, Capture Antibody - Q2383907	Q2383907

参考

参考概述	公共医疗ID
Sandwich immunoassay for soluble glycoprotein VI in patients with symptomatic coronary artery disease. Bigalke, Boris, et al. Clin. Chem., 57: 898-904 (2011) 2011 显示摘要 Platelet glycoprotein VI (pGPVI) expression is increased in acute coronary syndrome (ACS), reflecting platelet activation. There is no reliable method available to measure pGPVI. Our aim was to develop a bead-based sandwich immunoassay to measure soluble GPVI (sGPVI).	21474641

参考概述

公共医疗ID

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描述

ABS446

Anti-GPVI Antibody

显示价格及库存情况

MABT418

Anti-GPVI Antibody, clone 8A2, Detection Antibody

显示价格及库存情况

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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