数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABN794 Sigma-AldrichAnti-GLAST Antibody, clone 8C11.1

Anti-GLAST Antibody, clone 8C11.1 is an antibody against GLAST for use in Western Blotting, Immunohistochemistry .

Anti-GLAST Antibody, clone 8C11.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
技术信息

Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: SLC1A3, EAAT1, GLAST, GLAST1 UniProt Number: P43003

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, R	WB, IH(P)	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN794
Description	Anti-GLAST Antibody, clone 8C11.1
Alternate Names	Excitatory amino acid transporter 1 Sodium-dependent glutamate/aspartate transporter 1 GLAST-1 Solute carrier family 1 member 3 GLAST
Background Information	Excitatory amino acid transporter 1 (UniProt P43003; also known as GLAST-1, Sodium-dependent glutamate/aspartate transporter 1, Solute carrier family 1 member 3) is encoded by the SLC1A3 (also known as EA6, EAAT1, GLAST, GLAST1) gene in human (Entrez Gene ID 6507). GLAST-1 is a multitransmembrane protein that functions as a high affinity glutamate transporter and mediates the termination of postsynaptic action of glutamate in central nervous system by rapidly removing released glutamate from the synaptic cleft. GLAST-1 also transports L- and D-aspartate. GLAST gene mutations are linked to episodic ataxia type 6 (EA6), a disorder characterized by seizures, migraine, and alternating hemiplegia. There are 5 known spliced variants. Isoform 2 has no functional glutamate uptake activity and exerts a dominant negative effect against isoform 1.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG1λ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-GLAST Antibody, clone 8C11.1 is an antibody against GLAST for use in Western Blotting, Immunohistochemistry .
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected GLAST in human cerebellum and rat cerebellum tissue.

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to the extracellular domain of human GLAST.
Epitope	Extracellular domain
Clone	8C11.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Clone 8C11.1 epitope lies within the second extracellular segement of GLAST isoforms 1 & 2. The epitope region is also present in isoform 4, but not in isforms 3 & 5.
Isotype	IgG1λ
Species Reactivity	Human Rat
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_004163
Gene Symbol	SLC1A3 EAAT1 GLAST GLAST1
Purification Method	Protein G Purified
UniProt Number	P43003
Molecular Weight	~55 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human brain tissue lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected GLAST in 200 µg of human brain tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN794	04055977166644

Documentation

Anti-GLAST Antibody, clone 8C11.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-GLAST Antibody, clone 8C11.1 分析证书

标题	批号
Anti-GLAST, clone 8C11.1 - 3167609	3167609
Anti-GLAST, clone 8C11.1 - 3250991	3250991
Anti-GLAST, clone 8C11.1 - 3389915	3389915
Anti-GLAST, clone 8C11.1 - 3866884	3866884
Anti-GLAST, clone 8C11.1 - 3944522	3944522
Anti-GLAST, clone 8C11.1 - 4163455	4163455
Anti-GLAST, clone 8C11.1 -2710635	2710635
Anti-GLAST, clone 8C11.1 -2764892	2764892
Anti-GLAST, clone 8C11.1 -2814887	2814887
Anti-GLAST, clone 8C11.1 -Q2569068	Q2569068

技术信息

标题
White Paper: Further considerations of antibody validation and usage.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

此产品已添加到您的购物车。