Millipore Sigma Vibrant Logo

MABC545 Anti-FANCM Antibody, clone CV5.1

Detect FANCM using this Anti-FANCM Antibody, clone CV5.1 validated for use in ICC.

Anti-FANCM Antibody, clone CV5.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Apoptosis - Additional Gene Symbol: FANCM UniProt Number: Q8IYD8
View Products on Sigmaaldrich.com
MABC545
100 µL  
正在检索价格......
无法检索价格。
最小订购数量为倍数
Maximum Quantity is
以订单确认为准 更多信息
您节约了 ()。
 
—
Request Pricing
—
目前缺货 目前缺货
有货 
停产
少量现货
供货情况有待确认
    其余：另行通知
      其余：另行通知
      另行通知
      联系客户服务
      Contact Customer Service

      特卖

       

      联系客户服务

      概述

      Replacement Information

      特卖

      100% Performance Guaranteed

      重要规格表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC545
      DescriptionAnti-FANCM Antibody, clone CV5.1
      Alternate Names
      • Fanconi anemia group M protein
      • Protein FACM
      • ATP-dependent RNA helicase FANCM
      • Fanconi anemia-associated polypeptide of 250 kDa
      • FAAP250
      • Protein Hef ortholog
      Background InformationFANCM, also known as Fanconi anemia group M protein (FACM), or ATP-dependent RNA helicase FANCM, or Fanconi anemia-associated polypeptide of 250 kDa (FAAP250), or Protein Hef ortholog, and encoded by the gene FANCM/KIAA1596,is a critical ATPase needed for proper DNA repair. FANCM is found at DNA replication forks and required for cellular resistance to DNA cross-linking agents and for proper DNA repair. FANCM belongs to a multi-subunit FA (Fanconi anemia) complex. FANCM is localized to the nucleus and expressed in most cells. Defects in FANCM may be associated with Fanconi anemia complementation group M (FANCM) a disorder affecting hematopoietic cells can causing anemia, leukopenia and thrombopenia. Patients also have cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition toward malignancies. Patient’s cells show hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect FANCM using this Anti-FANCM Antibody, clone CV5.1 validated for use in ICC.
      Key Applications
      • Immunocytochemistry
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to human FANCM.
      CloneCV5.1
      Concentration0.5 mg/mL
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FANCM
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight230 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry Analysis in A431, HeLa, and HepG2 cells.

      Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected FANCM in A431, HeLa, and HepG2 cells.

      Dylight® is a registered trademark of Thermo Fisher Scientific.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      MABC545 04053252976315