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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABC269 Sigma-AldrichAnti-FANCC Antibody, clone 9A3.1

Anti-FANCC Antibody, clone 9A3.1 is an antibody against FANCC for use in Immunohistochemistry and Immunocytochemistry (Paraffin).

Anti-FANCC Antibody, clone 9A3.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
技术信息

Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: FANCC, FAC, FACC UniProt Number: Q00597

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IH(P)	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABC269
Description	Anti-FANCC Antibody, clone 9A3.1
Alternate Names	FANCC Fanconi anemia group C protein Protein FACC
Background Information	Fanconi anemia (FA) is an inherited bone marrow failure syndrome associated with a progressive decline in hematopoietic stem cells, developmental defects, and predisposition to cancer. FANCC is part of the multisubunit Fanconi anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCC is a primarily nuclear localized DNA repair protein that is believed to function in interstrand DNA cross-link repair and the maintenance of normal chromosome stability. Mutations in FANCC are associated with various aspects of FA. New research shows that FANCC is critical for resistance to DNA cross-linking drug-induced DNA damage in cells of patients with myeloproliferative neoplasms. Also, FANCC interacts with the C-terminal-binding protein-1 (CtBP1) involved in transcriptional regulation, including being a negative regulator of Dickkopf-1 (DKK1) expression. This down regulation does not occur in mutations of FANCC, which then leads to up-regulation of DKK1, a molecule involved in hematopoietic malignancies.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ300

Applications
Application	Anti-FANCC Antibody, clone 9A3.1 is an antibody against FANCC for use in Immunohistochemistry and Immunocytochemistry (Paraffin).
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FANCC in human ileum and human kidney tissue.

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to human FANCC.
Clone	9A3.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_000127
Gene Symbol	FANCC FAC FACC
Purification Method	Protein G Purified
UniProt Number	Q00597
Molecular Weight	~65 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human testis tissue lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected FANCC in 10 µg of human testis tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABC269	04055977136258

Documentation

Anti-FANCC Antibody, clone 9A3.1 分析证书

标题	批号
Anti-FANCC, clone 9A3.1 - 3904357	3904357
Anti-FANCC, clone 9A3.1 -Q2553947	Q2553947

技术信息

标题
White Paper: Further considerations of antibody validation and usage.

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描述

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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