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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABC524 Sigma-AldrichAnti-FANCC Antibody, clone 8F3

This Anti-FANCC Antibody, clone 8F3 is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry for the detection of FANCC.

Anti-FANCC Antibody, clone 8F3 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: FANCC, FAC, FACC UniProt Number: Q00597

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R, M, H	WB, IP, ICC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABC524
Description	Anti-FANCC Antibody, clone 8F3
Alternate Names	Fanconi anemia group C protein Protein FACC FANCC
Background Information	Fanconi anemia (FA) is an inherited bone marrow failure syndrome associated with a progressive decline in hematopoietic stem cells, developmental defects, and predisposition to cancer. FANCC is part of the multisubunit Fanconi anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCC is a primarily nuclear localized DNA repair protein that is believed to function in interstrand DNA cross-link repair and the maintenance of normal chromosome stability. Mutations in FANCC are associated with various aspects of FA. New research shows that FANCC is critical for resistance to DNA cross-linking drug-induced DNA damage in cells patients with myeloproliferative neoplasms. Also, FANCC interacts with the C-terminal-binding protein-1 (CtBP1) involved in transcriptional regulation, including being a negative regulator of Dickkopf-1 (DKK1) expression. This down regulation does not occur in mutations of FANCC, which then leads to up-regulation of DKK1, a molecule involved in hematopoietic malignancies.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-FANCC Antibody, clone 8F3 is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry for the detection of FANCC.
Key Applications	Western Blotting Immunoprecipitation Immunocytochemistry
Application Notes	Western Blotting Analysis: 4 µg/mL of a representative lot of this antibody detected FANCC in 10 µg of Mouse brain lysate. Western Blotting Analysis: A representative lot detected FANCC in HeLa cell lysate (Tremblay, C.S., et al. (2008) Blood. 112(5):2062-2070). Immunoprecipitation Analysis: A representative lot immunoprecipitated FANCC from HeLa cell lysate (Tremblay, C.S., et al. (2008) Blood. 112(5):2062-2070). Immunocytochemistry Analysis: A representative lot detected FANCC in HeLa cells (Tremblay, C.S., et al. (2008) Blood. 112(5):2062-2070).

Biological Information
Immunogen	Linear peptide corresponding to Human FANCC.
Clone	8F3
Concentration	1 mg/mL
Host	Mouse
Isotype	IgG2bκ
Species Reactivity	Rat Mouse Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_000127
Gene Symbol	FANCC FAC FACC
Purification Method	Protein G Purified
UniProt Number	Q00597
Molecular Weight	~ 63 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in PC12 cell lysate. Western Blotting Analysis: 4 µg/mL of this antibody detected FANCC in 10 µg of PC12 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	200 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABC524	04053252983597

Documentation

Anti-FANCC Antibody, clone 8F3 MSDS

职位
物料安全数据表 (MSDS)

Anti-FANCC Antibody, clone 8F3 分析证书

标题	批号
Anti-FANCC, clone 8F3 - Q2442268	Q2442268
Anti-FANCC, clone 8F3 - 3167562	3167562
Anti-FANCC, clone 8F3 - 3500939	3500939
Anti-FANCC, clone 8F3 - 3671313	3671313
Anti-FANCC, clone 8F3 - 3872370	3872370

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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