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07-1386 Sigma-AldrichAnti-Connective Tissue Growth Factor Antibody

Anti-Connective Tissue Growth Factor Antibody detects level of Connective Tissue Growth Factor & has been published & validated for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: CTGF, CCN2, HCS24, IGFBP8, NOV2 UniProt Number: P29279

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概述

Replacement Information

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	Gt	Purified	Polyclonal Antibody

Description
Catalogue Number	07-1386
Description	Anti-Connective Tissue Growth Factor Antibody
Alternate Names	Hypertrophic chondrocyte-specific protein 24 connective tissue growth factor insulin-like growth factor-binding protein 8
Background Information	Connective Tissue Growth Factor (CTGF) is a member of the CNN family of growth factors that are characterized as having cysteine-rich peptides with four specific domains. CTGF was originally identified in endothelial cells as a significant chemotactic and mitogenic factor. Research has revealed CTGF to have several biological properties which include chemotaxis, cell proliferation, promotion of adhesion and the formation of extracellular matrix. It is also necessary for such biological processes as wound healing, scar formation, fibrosis, embryogenesis and angiogenesis. In its role as an inducer of angiogenesis, CTGF has been associated with vascular endothelial growth factor (VEGF). As a result of its pro-fibrotic properties, CTGF is thought to be a promising target for therapy in conditions involving pathological fibrosis such as chronic fibrotic disease, chronic kidney disease and proliferative diabetic retinopathy (PDR). Cell types found to express CTGF are endothelial cells, fibroblasts and vascular smooth-muscle cells.

References

Product Information
Format	Purified
Control	Untreated and TGFb1 treated NRK cell lysates
Presentation	Purified goat polyclonal in buffer containing Tris-Glycine pH 8.0 with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-Connective Tissue Growth Factor Antibody detects level of Connective Tissue Growth Factor & has been published & validated for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	Recombinant protein corresponding to the mature chain of human Connective tissue growth factor.
Epitope	Mature chain
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Goat
Specificity	This antibody recognizes the mature chain of Connective tissue growth factor.
Species Reactivity	Human
Species Reactivity Note	Demonstrated to react with Human. Primate (98% sequence homolgy). Monkey (97% sequence homology). Porcine and Bovine (93% sequence homology). Rat and mouse (91% sequence homology).
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_001892.1
Entrez Gene Summary	The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq].
Gene Symbol	CTGF CCN2 HCS24 IGFBP8 NOV2
Purification Method	Protein G Purified
UniProt Number	P29279
UniProt Summary	FUNCTION: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. SUBCUNIT STRUCTURE: Monomer. SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix By similarity. Secreted By similarity. SEQUENCE SIMILARITIES: Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain.
Molecular Weight	In Western Blot, full length CTGF is observed at 38 kDa and CTGF N&C domain is observed at 19 kDa.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in untreated and TGFb1 treated NRK cell lysates. Western Blot Analysis: 5 µg/mL of this antibody detected Connective tissue growth factor on 10 µg of untreated and TGFb1 treated NRK cell lysates.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
07-1386	04053252411090

Documentation

Anti-Connective Tissue Growth Factor Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-Connective Tissue Growth Factor Antibody 分析证书

标题	批号
Anti-Connective Tissue Growth Factor	3075659
Anti-Connective Tissue Growth Factor	2474951
Anti-Connective Tissue Growth Factor - 2201497	2201497
Anti-Connective Tissue Growth Factor - 3990663	3990663
Anti-Connective Tissue Growth Factor - NG1928923	NG1928923
Anti-Connective Tissue Growth Factor - NRG1719645	NRG1719645
Anti-Connective Tissue Growth Factor -2568178	2568178
Anti-Connective Tissue Growth Factor -2786964	2786964

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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