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AB757P Anti-Collagen Type III Antibody

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AB757P
100 µg  
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      概述

      Replacement Information

      重要规格表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RELISA, RIA, IHCRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB757P
      ReplacesAB757
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Collagen Type III Antibody
      OverviewCollagen Type III extracted and purified from rat skin. Antibody shows less than 0.1% reactivity with rat Collagen Type I and rat Elastin with less than 10.0% reactivity with rat Collagen Type V.
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      PresentationAffinity purified immunoglobulin. Liquid, containing 0.01M phosphate, 0.09M NaCl, pH 7.2. No preservatives.
      Quality LevelMQ100
      Applications
      ApplicationDetect Collagen Type III using this Anti-Collagen Type III Antibody validated for use in ELISA, RIA, IH.
      Key Applications
      • ELISA
      • Radioimmunoassay
      • Immunohistochemistry
      Applications Not Recommended
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry: 1:80 dilution for immunofluorescent staining of frozen rat skin and liver tissues.

      Radioimmunoassay

      ELISA: 1:1000

      Not recommended for paraffin tissue sections or Western blots.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRat Type III 100%

      Rat Type I < 0.1%

      Rat Type V 9%

      Mouse Type III 9%

      Human Type I < 0.1%

      Rat Elastin < 0.1%
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]
      Gene Symbol
      • COL3A1
      • EDS4A
      • FLJ34534
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02461 # Collagen type III occurs in most soft connective tissues along with type I collagen.
      SIZE: 1466 amino acids; 138564 Da
      SUBUNIT: Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
      PTM: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
      DISEASE: SwissProt: P02461 # Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type III (EDS-III) [MIM:130020]; also known as benign hypermobility syndrome. Inheritance is autosomal dominant. EDS is characterized by joint laxity and hyperextensible skin. It is divided into nine different subtypes based on biochemical and clinical variations. & Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type IV (EDS-IV) [MIM:130050]. EDS-IV is the most severe form of the disease, in that it often produces life-threatening consequences, such as rupture of the arteries, bowel, or uterus. A variant form of EDS-IV is Gottron type acrogeria [MIM:201200]. The main characteristics are atrophy and mottled-type hyperpigmentation of the acral skin, resulting in an aged appearance. & Defects in COL3A1 may be a cause of aortic aneurysm [MIM:100070]. Aortic aneurysm consists of a dangerous ballooning of the aorta which is caused by a defect in the artery's wall.
      SIMILARITY: SwissProt: P02461 ## Belongs to the fibrillar collagen family. & Contains 1 VWFC domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      AB757P 04053252583056

      Documentation

      Anti-Collagen Type III Antibody MSDS

      职位

      物料安全数据表 (MSDS) 

      Anti-Collagen Type III Antibody 分析证书

      标题批号
      RABBIT ANTI-RAT COLLAGEN TYPE III 2433277
      RABBIT ANTI-RAT COLLAGEN TYPE III -2882737 2882737
      RABBIT ANTI-RAT COLLAGEN TYPE III POLYCLONAL ANTIBODY 3143229
      RABBIT ANTI-RAT COLLAGEN TYPE III POLYCLONAL ANTIBODY - 2024523 2024523

      参考

      参考概述公共医疗ID
      Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model.
      Shunsuke Takahashi, Yoshihiko Taniguchi, Ayumu Nakashima, Tetsuji Arakawa, Toru Kawai, Shigehiro Doi, Takafumi Ito, Takao Masaki, Nobuoki Kohno, Noriaki Yorioka, Shunsuke Takahashi, Yoshihiko Taniguchi, Ayumu Nakashima, Tetsuji Arakawa, Toru Kawai, Shigehiro Doi, Takafumi Ito, Takao Masaki, Nobuoki Kohno, Noriaki Yorioka
      Nephron. Experimental nephrology  112  e59-69  2009

      显示摘要
      19390220 19390220
      Formation of smooth muscle alpha actin filaments in CD34+ bone marrow cells on arterial elastic laminae: potential role of SH2 domain-containing protein tyrosine phosphatase-1.
      Shu Q Liu, Brandon J Tefft, Andy Zhang, Li-Qun Zhang, Yu H Wu
      Matrix biology : journal of the International Society for Matrix Biology  27  282-94  2008

      显示摘要
      18258420 18258420
      MR three-dimensional molecular imaging of intramural biomarkers with targeted nanoparticles.
      Tillmann Cyrus, Dana R Abendschein, Shelton D Caruthers, Thomas D Harris, Veronica Glattauer, Jerome A Werkmeister, John A M Ramshaw, Samuel A Wickline, Gregory M Lanza
      Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance  8  535-41  2006

      显示摘要
      16755843 16755843

      数据表

      标题
      RABBIT ANTI-RAT COLLAGEN TYPE III

      相关产品和应用

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      产品族

      种类

      Life Science Research > Antibodies and Assays > Primary Antibodies