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MABN486 Sigma-AldrichAnti-Co-Rest/RCOR1 Antibody, clone K72/8

Anti-Co-Rest/RCOR1 Antibody, clone K72/8 is a highly specific mouse monoclonal antibody, that targets CoRest & has been tested in western blotting, IHC & ICC.

Anti-Co-Rest/RCOR1 Antibody, clone K72/8 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: RCOR1, KIAA0071, RCOR UniProt Number: Q9UKL0

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概述

Replacement Information

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R	WB, IHC, ICC	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABN486
Description	Anti-Co-Rest/RCOR1 Antibody, clone K72/8
Alternate Names	REST corepressor 1 Protein CoREST
Background Information	REST corepressor 1(RCOR1, CoREST) is an essential component of the BHC corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. RCOR1 also promotes the demethylase activity of KDM1A on core histones and nucleosomal substrates and plays a central role in demethylation of Lys-4 of histone H3. Furthermore, RCOR1 is a component of a RCOR/GFI/KDM1A/HDAC complex that suppresses a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. RCOR1 is ubiquitously expressed and is primarily found in the nucleus, but is partially translocated into the cytoplasm upon HSV-1 infection.

References

Product Information
Format	Purified
Control	Jurkat cell lysate
Presentation	Purified mouse monoclonal IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-Co-Rest/RCOR1 Antibody, clone K72/8 is a highly specific mouse monoclonal antibody, that targets CoRest & has been tested in western blotting, IHC & ICC.
Key Applications	Western Blotting Immunohistochemistry Immunocytochemistry
Application Notes	Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Co-Rest/RCOR1 in human stomach tissue. Immunocytochemistry Analysis: A representative lot detected Co-Rest/RCOR1 in COS-1 cells expressing Myc-tagged Co-Rest. (Prof. J. Trimmer, University of California, Davis.).

Biological Information
Immunogen	Recombinant protein corresponding to human Co-Rest/RCOR1.
Clone	clone K72/8
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	This antibody may cross react with human RCOR3 based upon 70% sequence homology.
Isotype	IgG1
Species Reactivity	Human Mouse Rat
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_055971
Gene Symbol	RCOR1 KIAA0071 RCOR
Purification Method	Protein G Purified
UniProt Number	Q9UKL0
Molecular Weight	~ 65 kDa observed. The calculated molecular weight is 53 kDa, however Co-Rest/RCOR1 has been shown as a ~65-70 kDa band in western blots (You, A., et al. (2001). National Academy of Sciences. 98(4):1454-1458)(Min, G. L., et al. (2005). Nature. 437:432-435).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in Jurkat cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected Co-Rest/RCOR1 in 10 µg of Jurkat cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABN486	04053252888571

Documentation

Anti-Co-Rest/RCOR1 Antibody, clone K72/8 MSDS

职位
物料安全数据表 (MSDS)

Anti-Co-Rest/RCOR1 Antibody, clone K72/8 分析证书

标题	批号
Anti-Co-Rest/RCOR1, clone K72/8 - Q2166801	Q2166801
Anti-Co-Rest/RCOR1, clone K72/8 - 3329558	3329558
Anti-Co-Rest/RCOR1, clone K72/8 - 3501802	3501802
Anti-Co-Rest/RCOR1, clone K72/8 - 3733769	3733769
Anti-Co-Rest/RCOR1, clone K72/8 - 3992275	3992275
Anti-Co-Rest/RCOR1, clone K72/8 -2556929	2556929

Related Products

产品目录编号

描述

07-455

Anti-CoREST Antibody

显示价格及库存情况

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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