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MABS1163 Sigma-AldrichAnti-CSF-1R/CD115 Antibody clone FER216

Anti-CSF-1R/CD115 Antibody clone FER216 is an antibody against CSF-1R for use in Western Blotting.

Anti-CSF-1R/CD115 Antibody clone FER216 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Signaling Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: CSF1R, CSFR, FMS, HDLS UniProt Number: P07333

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概述

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABS1163
Description	Anti-CSF-1R/CD115 Antibody clone FER216
Alternate Names	Macrophage colony-stimulating factor 1 receptor CD115 CSF-1 receptor CSF-1-R CSF-1R M-CSF-R Proto-oncogene c-Fms
Background Information	Macrophage colony-stimulating factor 1 receptor (EC 2.7.10.1; UniProt P07333; also known as CD115, CSF-1 receptor, CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms) is encoded by the CSF1R (also known as CSFR, FMS, HDLS) gene (Gene ID 1436) in human. CSF1R is a CSF1/PDGF family receptor tyrosine kinase that mediates macrophage colony stimulating factor 1 (M-CSF1) and IL-34 signaling by acting as the receptor for these two cytokines. CSF1R plays a key role in the differentiation, recruitment and activation of tissue macrophages. Tumor-associated macrophages (TAMs) have been associated with survival in classic Hodgkin lymphoma (cHL) and other lymphoma types. Hyperphosphorylated CSF1R is found in cHL tissue and highlights the importance of CSF1/CSF1R signaling in the recruitment of TAMs. CSF1R is initially produced with a signal peptide sequence (a.a. 1-19), the removal of which yields the mature type I single transmembrane protein with an extracellular region (a.a. 20-517), a transmembrane segment (a.a. a.a. 518-538), and a cytoplasmic region (a.a. 539-972) that contains the kinase domain (a.a. 582-910).

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-CSF-1R/CD115 Antibody clone FER216 is an antibody against CSF-1R for use in Western Blotting.
Key Applications	Western Blotting
Application Notes	Western Blotting Analysis: 1.0 µg/mL from a representative lot detected CSF-1R/CD115 in 10 µg of human tonsil tissue lysate.

Biological Information
Immunogen	Human IgG1 Fc-tagged recombinant human CSF-1R/CD115 extracellular domain.
Epitope	Extracellular domain.
Clone	FER216
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Clone FER216 reacts with the extracellular domain of human CSFR1, but not the extracellular domain of human FGFR1. Clone FER216 detected the ~100 kDa human CSFR1 in nomral tonsil and Hodgkin lymphoma (cHL) tissue extracts, as well as an additional ~150 kDa phosphorylated CSFR1 band in cHL tissue extracts (Martín-Moreno, A.M., et al. (2015). PLoS One. 2015 Jun 12;10(6):e0125203).
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_005202
Gene Symbol	CSF1R CSFR FMS HDLS
Purification Method	Protein G Purified
UniProt Number	P07333
Molecular Weight	~107 kDa observed. Uncharacterized band(s) may appear in some lysates.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in human colon tissue lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected CSF-1R/CD115 in 10 µg of human colon tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABS1163	04055977314281

Documentation

Anti-CSF-1R/CD115 Antibody clone FER216 MSDS

职位
物料安全数据表 (MSDS)

Anti-CSF-1R/CD115 Antibody clone FER216 分析证书

标题	批号
Anti-CSF-1R/CD115, clone FER216 - 3174760	3174760
Anti-CSF-1R/CD115, clone FER216 - 3280061	3280061
Anti-CSF-1R/CD115, clone FER216 - 3862594	3862594
Anti-CSF-1R/CD115, clone FER216 - 3906402	3906402
Anti-CSF-1R/CD115, clone FER216 - 3991572	3991572
Anti-CSF-1R/CD115, clone FER216 - 4023281	4023281
Anti-CSF-1R/CD115, clone FER216 - 4061835	4061835
Anti-CSF-1R/CD115, clone FER216 -2751108	2751108
Anti-CSF-1R/CD115, clone FER216 -2762050	2762050
Anti-CSF-1R/CD115, clone FER216 -Q2641929	Q2641929

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描述

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Anti-Fms/CSF-1 Receptor Antibody, extracellular domain

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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