数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

PC711 Sigma-AldrichAnti-CHIP Rabbit pAb

This Anti-CHIP Rabbit pAb is validated for use in Immunoblotting for the detection of CHIP.

Anti-CHIP Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: Anti-Carboxyl Terminus of Hcs70-Interacting Protein

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概述

Replacement Information

重要规格表

Species Reactivity	Host	Antibody Type
Dr, Ht, H, Mk, M, R	Rb	Polyclonal Antibody

价格及供货情况

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Description
Overview	Recognizes the ~35 kDa CHIP protein. May also detect bands at ~43, ~51, and ~70 kDa corresponding to the mono-ubiquitinated, di-ubiquitinated, and dimeric forms of CHIP, respectively.
Catalogue Number	PC711
Brand Family	Calbiochem®
Synonyms	Anti-Carboxyl Terminus of Hcs70-Interacting Protein

References
References	Xu, W., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 12847. Demand, J., et al. 2001. Curr. Biol. 11, 1569. Connell, P., et al. 2001. Nat. Cell Biol. 3, 93. Jiang. J., et al. 2001. J. Biol. Chem. 276, 42938. Meacham, G.C., et al. 2001. Nat. Cell. Biol. 3, 100. Ballinger, C.A., et al. 1999. Mol. Cell. Biol. 19, 4535.

Product Information
Form	Liquid
Formulation	Undiluted serum.
Positive control	COS-7 cells
Preservative	≤0.1% Sodium azide
Quality Level	MQ100

Applications
Key Applications	Immunoblotting (Western Blotting) Immunofluorescence Immunoprecipitation
Application Notes	Immunoblotting (1:200-1:1000) Immunofluorescence (1:250) Immunoprecipitation (1:20)
Application Comments	May also detect bands at 43, 51, and 70 kDa, wich correspond to the mono-ubiquitinated, di-ubiquitinated, and dimeric forms of CHIP, respectively. Antibody should be titrated for optimal results in individual systems.

Biological Information
Immunogen	a recombinant protein consisting of full-length human CHIP fused to a His•Tag® sequence
Host	Rabbit
Isotype	IgG
Species Reactivity	Drosophila Hamster Human Monkey Mouse Rat
Antibody Type	Polyclonal Antibody

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	-20°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
PC711-100ULCN	04055977207897

Documentation

Anti-CHIP Rabbit pAb MSDS

职位
物料安全数据表 (MSDS)

Anti-CHIP Rabbit pAb 分析证书

标题	批号
PC711	输入批号

参考

参考信息概述
Xu, W., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 12847. Demand, J., et al. 2001. Curr. Biol. 11, 1569. Connell, P., et al. 2001. Nat. Cell Biol. 3, 93. Jiang. J., et al. 2001. J. Biol. Chem. 276, 42938. Meacham, G.C., et al. 2001. Nat. Cell. Biol. 3, 100. Ballinger, C.A., et al. 1999. Mol. Cell. Biol. 19, 4535.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-October-2018 JSW
Synonyms	Anti-Carboxyl Terminus of Hcs70-Interacting Protein
Application	Immunoblotting (1:200-1:1000) Immunofluorescence (1:250) Immunoprecipitation (1:20)
Description	Rabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~35 kDa CHIP protein.
Background	CHIP is a U-box dependent E3 ubiquitin ligase and a co-chaperone protein that interacts with Hsc70 and Hsp90 regulating protein triage decisions between folding and degradation. This occurs through CHIP remodeling the complexes to favor substrate degradation thus providing a molecular link between the chaperone and proteosome machinery. CHIP has been reported to be involved in the degradation of c-ErbB2/c-Neu, the glucocorticoid receptor, and the cystic fibrosis transmembrane-conductance regulator. CHIP expression shortens the half-life of both the nascent and mature ErbB2 protein.
Host	Rabbit
Immunogen	a recombinant protein consisting of full-length human CHIP fused to a His•Tag® sequence
Isotype	IgG
Species	Drosophila, hamster, human, monkey, mouse, rat
Positive control	COS-7 cells
Form	Liquid
Formulation	Undiluted serum.
Preservative	≤0.1% Sodium azide
Comments	May also detect bands at 43, 51, and 70 kDa, wich correspond to the mono-ubiquitinated, di-ubiquitinated, and dimeric forms of CHIP, respectively. Antibody should be titrated for optimal results in individual systems.
Storage	Avoid freeze/thaw -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Standard Handling
References	Xu, W., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 12847. Demand, J., et al. 2001. Curr. Biol. 11, 1569. Connell, P., et al. 2001. Nat. Cell Biol. 3, 93. Jiang. J., et al. 2001. J. Biol. Chem. 276, 42938. Meacham, G.C., et al. 2001. Nat. Cell. Biol. 3, 100. Ballinger, C.A., et al. 1999. Mol. Cell. Biol. 19, 4535.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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