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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABT419 Sigma-AldrichAnti-CD2AP Antibody, clone 2A2.1

This Anti-CD2AP Antibody, clone 2A2.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of CD2AP.

Anti-CD2AP Antibody, clone 2A2.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
技术信息

Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: CD2AP UniProt Number: Q9Y5K6

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IH(P)	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABT419
Description	Anti-CD2AP Antibody, clone 2A2.1
Alternate Names	CD2-associated protein CD2AP Adapter protein CMS Cas ligand with multiple SH3 domains
Background Information	CD2-associated protein (UniProt Q9Y5K6; also known as Adapter protein CMS, Cas ligand with multiple SH3 domains) is encoded by the CD2AP (also known as CMS) gene (Gene ID 23607) in human. CD2AP is an adapter protein expressed in all tissues except brain. CD2AP harbors three SH3 domains at its N-terminal, a proline-rich domain, and a C-terminal leucine-zipper domain that mediates CD2AP homodimerization. CD2AP is known to interact with actin-associated proteins, such as cortactin, and actin capping protein CAPZ. The SH3 domains of CD2AP mediate its association to the hypervariable C terminal region of Rac1, allowing CD2AP to act as a linker between Rac1 and the actin-binding proteins cortactin and CAPZ. CD2AP also plays an important role in the formation of the slit diaphragm in the kidney glomerulus between podocyte foot processes by linking the cell-cell adhesion protein nephrin to the cytoskeleton. CD2AP gene mutations are associated with kidney diseases such as sporadic nephrotic syndrome and focal segmental glomerulosclerosis.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	This Anti-CD2AP Antibody, clone 2A2.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of CD2AP.
Key Applications	Western Blotting Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected CD2AP in human kidney and human colon tissue.

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to the C-terminal half of human CD2AP.
Epitope	Internal (C-terminal half)
Clone	2A2.1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_036252
Gene Symbol	CD2AP
Purification Method	Protein G Purified
UniProt Number	Q9Y5K6
Molecular Weight	~71 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in Raji cell lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected CD2AP in 10 µg of Raji cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 μg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABT419	04055977277043

Documentation

Anti-CD2AP Antibody, clone 2A2.1 MSDS

职位
物料安全数据表 (MSDS)

Anti-CD2AP Antibody, clone 2A2.1 分析证书

标题	批号
Anti-CD2AP, clone 2A2.1 - 3474112	3474112
Anti-CD2AP, clone 2A2.1 -Q2595864	Q2595864

技术信息

标题
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White Paper: Further considerations of antibody validation and usage.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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