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CBL582 Anti-CD19 Antibody, clone HD37

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CBL582
100 µg  
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      概述

      重要规格表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IP, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL582
      ReplacesCBL1322
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD19 Antibody, clone HD37
      Alternate Names
      • B-lymphocyte Surface Antigen B4
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CD19 Antibody, clone HD37 detects level of CD19 & has been published & validated for use in FC, IP, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesIdentification of CD19 positive B lymphocytes and malignant B cells by indirect immunofluorescence staining

      Leukaemia and lymphoma phenotyping

      Identification of normal and malignant CD19 positive B lymphocytes in cryostat frozen sections

      Immunoprecipitation of the CD19 antigen

      Studies of the CD19/21 complex in B cell activation and the control of B cell development

      Optimal working dilutions must be determined by the end user.
      Biological Information
      CloneHD37
      HostMouse
      SpecificityThe CD19 antigen (90 kDa) is expressed from the earliest stages of B-progenitor development, on all peripheral B cells including germinal centre B cells and all B cell lines and B cell leukaemias tested. T cell and monocytic cell lines are negative and the antigen is lost on B cell maturations to plasma cells. The antigen is a type I integral membrane glycoprotein whose in vitro inhibition will influence B cell activation and proliferation.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryLymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
      Gene Symbol
      • CD19
      • B4
      • MGC12802
      • Leu-12
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P15391 # Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
      SIZE: 556 amino acids; 61128 Da
      SUBUNIT: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      DISEASE:SwissProt: P15391 # Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].
      SIMILARITY: SwissProt: P15391 ## Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      产品目录编号 GTIN
      CBL582 04053252512643