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MABF508 Sigma-AldrichAnti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98

This rat monoclonal antibody Anti-CD115 (c-fms) (mouse), PE, clone AFS98 validated for use in western blotting & Flow Cytometry for the detection of CD115 (c-fms).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Inflammation & Immunology Gene Symbol: Csf1r, Csfmr, Fms UniProt Number: P09581

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	FC, WB	R	PE	Monoclonal Antibody

Description
Catalogue Number	MABF508
Description	Anti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98
Alternate Names	Macrophage colony-stimulating factor 1 receptor CSF-1 receptor CSF-1-R CSF-1R M-CSF-R Proto-oncogene c-Fms CD115 CSF1-R
Background Information	The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralization of CSF-1 Receptor.

References

Product Information
Format	PE
Presentation	Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Quality Level	MQ100

Applications
Application	This rat monoclonal antibody Anti-CD115 (c-fms) (mouse), PE, clone AFS98 validated for use in western blotting & Flow Cytometry for the detection of CD115 (c-fms).
Key Applications	Flow Cytometry Western Blotting

Biological Information
Immunogen	Immunogen information for this antibody is proprietary information.
Clone	AFS98
Concentration	0.2 mg/mL
Host	Rat
Isotype	IgG2aκ
Species Reactivity	Mouse
Antibody Type	Monoclonal Antibody
Gene Symbol	Csf1r Csfmr Fms
Purification Method	Size Exclusion Chromatography
UniProt Number	P09581

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.125 µg of this antibody detected CD115 (c-fms) in one million C57Bl/6 peripheral blood cells.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Packaging Information
Material Size	25 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABF508	04053252979330

Documentation

Anti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98 MSDS

职位
物料安全数据表 (MSDS)

Anti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98 分析证书

标题	批号
Anti-CD115 (c-fms) (mouse), PE, clone AFS98 - TN14020702	TN14020702

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产品目录编号

描述

MABF509

Anti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98

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种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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